Tert-butyl 2-fluoro-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzoate

Base Information

Chemical Name:Tert-butyl 2-fluoro-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzoate
CAS No.:1263483-75-5
Molecular Formula:C₂₇H₂₉FN₄O₅
Molecular Weight:508.549
Hs Code.:

Synonyms:Tert-butyl 2-fluoro-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzoate

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Chemical Property of Tert-butyl 2-fluoro-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzoate

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Technology Process of Tert-butyl 2-fluoro-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzoate

There total 5 articles about Tert-butyl 2-fluoro-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1263483-74-4
tert-butyl 4-amino(hydroxyimino)methyl-2-fluorobenzoate

: 1263320-65-5
(2R)-2-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]butyric acid

: 1263483-75-5
Tert-butyl 2-fluoro-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzoate

Guidance literature:: (2R)-2-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]butyric acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

tert-butyl 4-amino(hydroxyimino)methyl-2-fluorobenzoate; In N,N-dimethyl-formamide; at 100 ℃; for 14h;

Reference yield:

: 872018-02-5
tert-butyl 4-cyano-2-fluorobenzoate

: 1263483-75-5
Tert-butyl 2-fluoro-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine / ethanol; water; tetrahydrofuran / 2 h / 80 °C

2.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 14 h / 100 °C

With hydroxylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 767-00-0
4-cyanophenol

: 1263483-75-5
Tert-butyl 2-fluoro-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 7.5 h / 0 - 100 °C

2.1: sodium hydride / 1,4-dioxane; mineral oil / 0.17 h / 0 - 20 °C

2.2: 4 h / 80 °C

3.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 14 h / 100 °C

With sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;