3,5-difluoro-4-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]phenol

Base Information

• Chemical Name: 3,5-difluoro-4-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]phenol
• CAS No.: 1613300-97-2
• Molecular Formula: C₁₃H₁₄F₂N₂O₂
• Molecular Weight: 268.263
• Mol file: 1613300-97-2.mol

Synonyms:3,5-difluoro-4-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]phenol

Chemical Property of 3,5-difluoro-4-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-difluoro-4-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]phenol

There total 2 articles about 3,5-difluoro-4-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-difluoro-4-bromophenol (144292-32-0) + 2-methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propan-2-ol (1082503-77-2) → 3,5-difluoro-4-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]phenol (1613300-97-2)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; water; at 100 ℃; for 1h; Microwave irradiation; Inert atmosphere;

Reference yield:

4-bromo-3,5-difluoro-phenol (130191-91-2) + 2-methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propan-2-ol (1082503-77-2) → 3,5-difluoro-4-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]phenol (1613300-97-2)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + 3,5-difluoro-4-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]phenol (1613300-97-2) → 3,5-difluoro-4-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)phenyl trifluoromethanesulfonate (1613300-98-3)

Guidance literature:

With triethylamine; In dichloromethane;

upstream raw materials:

2,3-difluoro-4-bromophenol

2-methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propan-2-ol

4-bromo-3,5-difluoro-phenol

Downstream raw materials:

1-{4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]pyrazol-1-yl}-2-methylpropan-2-ol

3,5-difluoro-4-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)phenyl trifluoromethanesulfonate