1-{4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]pyrazol-1-yl}-2-methylpropan-2-ol

Base Information

Chemical Name:1-{4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]pyrazol-1-yl}-2-methylpropan-2-ol
CAS No.:1613300-99-4
Molecular Formula:C₁₉H₂₅BF₂N₂O₃
Molecular Weight:378.227
Hs Code.:

Synonyms:1-{4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]pyrazol-1-yl}-2-methylpropan-2-ol

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Chemical Property of 1-{4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]pyrazol-1-yl}-2-methylpropan-2-ol

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Technology Process of 1-{4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]pyrazol-1-yl}-2-methylpropan-2-ol

There total 4 articles about 1-{4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]pyrazol-1-yl}-2-methylpropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613300-98-3
3,5-difluoro-4-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)phenyl trifluoromethanesulfonate

: 73183-34-3
bis(pinacol)diborane

: 1613300-99-4
1-{4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]pyrazol-1-yl}-2-methylpropan-2-ol

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; for 4h; Microwave irradiation; Sealed tube; Inert atmosphere;

Reference yield:

: 1082503-77-2
2-methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propan-2-ol

: 1613300-99-4
1-{4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]pyrazol-1-yl}-2-methylpropan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; 2,6-di-tert-butyl-4-methyl-phenol; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

2: triethylamine / dichloromethane / 16 h / 80 °C

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Microwave irradiation; Sealed tube; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; potassium acetate; potassium carbonate; triethylamine; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1613300-97-2
3,5-difluoro-4-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]phenol

: 1613300-99-4
1-{4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]pyrazol-1-yl}-2-methylpropan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 16 h / 80 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Microwave irradiation; Sealed tube; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; triethylamine; In 1,4-dioxane; dichloromethane;