1-(4-chloro-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)piperidine-4-carboxylic acid

Base Information

Chemical Name:1-(4-chloro-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)piperidine-4-carboxylic acid
CAS No.:1383708-93-7
Molecular Formula:C₂₃H₂₀ClFN₂O₃
Molecular Weight:426.875
Hs Code.:

Synonyms:1-(4-chloro-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)piperidine-4-carboxylic acid

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Chemical Property of 1-(4-chloro-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)piperidine-4-carboxylic acid

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Technology Process of 1-(4-chloro-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)piperidine-4-carboxylic acid

There total 2 articles about 1-(4-chloro-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: C₂₄H₂₂ClFN₂O₃

: 1383708-93-7
1-(4-chloro-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)piperidine-4-carboxylic acid

Guidance literature:: C₂₄H₂₂ClFN₂O₃; With methanol; sodium hydroxide; at 0 - 50 ℃; for 1h;

With hydrogenchloride; In water; pH=1;

Reference yield:

: 2971-79-1
isonipecotic acid methyl ester

: 1367126-21-3
2,4-dichloro-6-[4-(4-fluoro-phenoxy)-phenyl]-pyridine

: 1383708-93-7
1-(4-chloro-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.33 h / 160 °C / Inert atmosphere; microwave irradiation

2.1: sodium hydroxide; methanol / 1 h / 0 - 50 °C

2.2: pH 1

With methanol; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dimethyl sulfoxide;