(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-((S)-4-carboxy-1-morpholin-4-ylmethyl-butyl) ester

Base Information

Chemical Name:(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-((S)-4-carboxy-1-morpholin-4-ylmethyl-butyl) ester
CAS No.:137238-62-1
Molecular Formula:C₂₈H₄₈N₂O₈
Molecular Weight:540.698
Hs Code.:

(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-((S)-4-carboxy-1-morpholin-4-ylmethyl-butyl) ester

Synonyms:(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-((S)-4-carboxy-1-morpholin-4-ylmethyl-butyl) ester

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Chemical Property of (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-((S)-4-carboxy-1-morpholin-4-ylmethyl-butyl) ester

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Technology Process of (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-((S)-4-carboxy-1-morpholin-4-ylmethyl-butyl) ester

There total 7 articles about (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-((S)-4-carboxy-1-morpholin-4-ylmethyl-butyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147505-11-1
(1R)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)pentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

: 137238-62-1
(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-((R)-4-carboxy-1-morpholin-4-ylmethyl-butyl) ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr;
DOI:10.1021/jm00099a004

Reference yield:

: 143508-53-6
(1S)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

: 137238-62-1
(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-((S)-4-carboxy-1-morpholin-4-ylmethyl-butyl) ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr;
DOI:10.1021/jm00099a004

Reference yield:

: 137238-88-1
4-Oxiranyl-butyric acid benzyl ester

: 137238-62-1
(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-((R)-4-carboxy-1-morpholin-4-ylmethyl-butyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: alumina / diethyl ether

2: 36 percent / 4-(dimethylamino)pyridine (DMAP), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC) / CH₂Cl₂ / 0 °C

3: H₂ / 10 percent Pd/C / methanol / 760 Torr

With dmap; aluminum oxide; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00099a004