(-)-Scopolamine

Base Information

• Chemical Name: (-)-Scopolamine
• CAS No.: 475199-31-6
• Molecular Formula: C₁₇H₂₁NO₄
• Molecular Weight: 303.358
• European Community (EC) Number: 200-090-3
• DSSTox Substance ID: DTXSID60858963
• Nikkaji Number: J1.587.795B
• Wikipedia: Scopolamine
• Wikidata: Q105260197
• NCI Thesaurus Code: C47712
• RXCUI: 9601
• Metabolomics Workbench ID: 123283
• ChEMBL ID: CHEMBL13030
• Mol file: 475199-31-6.mol

Synonyms:Boro Scopol;Boro-Scopol;Hyoscine;Isopto Hyoscine;Kwells;Scoburen;Scopace;Scopoderm TTS;Scopolamine;Scopolamine Cooper;Scopolamine Hydrobromide;Transderm Scop;Transderm V;Transderm-V;Travacalm HO;Vorigeno

Chemical Property of (-)-Scopolamine

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 303.14705815
• Heavy Atom Count: 22
• Complexity: 418

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4
• Recent ClinicalTrials: Efficacy and Safety of Escócia Association in the Treatment of Acute Pain
• Recent EU Clinical Trials: A single blind study comparing the efficacy of Glycopyrronium and Hyoscine on drooling in children with neurodisability - DRI Trial (Drooling Reduction Intervention)
• Recent NIPH Clinical Trials: Study of the upper gastrointestinal tract peristalsis inhibitory effect of acupuncture in endoscopic submucosal dissection for early gastric cancer: A randomized controlled trial.

Technology Process of (-)-Scopolamine

There total 1 articles about (-)-Scopolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Scopolamin (475199-31-6)

Guidance literature:

Aus d. Komponenten;

Reference yield: 88.0%

trimethylsilyl cyanide (7677-24-9) + Scopolamin (475199-31-6) → 3-Hydroxy-2-phenyl-propionic acid 9-cyanomethyl-3-oxa-9-aza-tricyclo[3.3.1.02,4]non-7-yl ester (131444-47-8)

Guidance literature:

With oxygen; N,N'-dimethyl-2,7-diazapyrene bis(tetrafluoroborate); In acetonitrile; at 20 ℃; for 2.3h; Irradiation;

DOI:10.1016/S0040-4039(00)97719-0

Reference yield:

Scopolamin (475199-31-6) → scopolamine (64069-63-2)

Guidance literature:

With acetic acid ester; ethanol; <(1R)-(endo,anti)>-(+)-3-bromocamphor-8-sulfonic acid;

Downstream raw materials:

scopolamine

3-Hydroxy-2-phenyl-propionic acid 9-cyanomethyl-3-oxa-9-aza-tricyclo[3.3.1.0^2,4]non-7-yl ester

N-butylhyoscinium bromide