16-[4-(5-phenyl-1H-pyrrol-3-yl)-benzyl]-1,4,7,10,13-pentaoxa-16-aza-cyclooctadecane

Base Information

Chemical Name:16-[4-(5-phenyl-1H-pyrrol-3-yl)-benzyl]-1,4,7,10,13-pentaoxa-16-aza-cyclooctadecane
CAS No.:934161-04-3
Molecular Formula:C₂₉H₃₈N₂O₅
Molecular Weight:494.631
Hs Code.:

16-[4-(5-phenyl-1<i>H</i>-pyrrol-3-yl)-benzyl]-1,4,7,10,13-pentaoxa-16-aza-cyclooctadecane

Synonyms:16-[4-(5-phenyl-1H-pyrrol-3-yl)-benzyl]-1,4,7,10,13-pentaoxa-16-aza-cyclooctadecane

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Chemical Property of 16-[4-(5-phenyl-1H-pyrrol-3-yl)-benzyl]-1,4,7,10,13-pentaoxa-16-aza-cyclooctadecane

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Technology Process of 16-[4-(5-phenyl-1H-pyrrol-3-yl)-benzyl]-1,4,7,10,13-pentaoxa-16-aza-cyclooctadecane

There total 5 articles about 16-[4-(5-phenyl-1H-pyrrol-3-yl)-benzyl]-1,4,7,10,13-pentaoxa-16-aza-cyclooctadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 934161-02-1
4-nitro-3-[4-(1,4,7,10,13-pentaoxa-16-aza-cyclooctadec-16-ylmethyl)-phenyl]-1-phenyl-butan-1-one

: 934161-04-3
16-[4-(5-phenyl-1H-pyrrol-3-yl)-benzyl]-1,4,7,10,13-pentaoxa-16-aza-cyclooctadecane

Guidance literature:: 4-nitro-3-[4-(1,4,7,10,13-pentaoxa-16-aza-cyclooctadec-16-ylmethyl)-phenyl]-1-phenyl-butan-1-one; With potassium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

With sulfuric acid; In tetrahydrofuran; methanol; at 0 - 20 ℃;

With ammonium acetate; acetic acid; at 100 ℃; for 1h;
DOI:10.1021/jo062506r

Reference yield:

: 934160-98-2
4-(1,4,7,10,13-pentaoxa-16-aza-cyclooctadec-16-ylmethyl)-benzaldehyde

: 934161-04-3
16-[4-(5-phenyl-1H-pyrrol-3-yl)-benzyl]-1,4,7,10,13-pentaoxa-16-aza-cyclooctadecane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / NaOH / methanol / 15 h / 20 °C

2.1: 96 percent / Et₂NH / methanol / 16 h / 70 °C

3.1: KOH / methanol; tetrahydrofuran / 1 h / 20 °C

3.2: H₂SO₄ / methanol; tetrahydrofuran / 0 - 20 °C

3.3: 49 percent / NH₄OAc; AcOH / 1 h / 100 °C

With potassium hydroxide; sodium hydroxide; diethylamine; In tetrahydrofuran; methanol; 2.1: Henry addition / 3.1: Nef reaction;
DOI:10.1021/jo062506r

Reference yield:

: 934161-00-9
3-[4-(1,4,7,10,13-pentaoxa-16-aza-cyclooctadec-16-ylmethyl)-phenyl]-1-phenyl-propenone

: 934161-04-3
16-[4-(5-phenyl-1H-pyrrol-3-yl)-benzyl]-1,4,7,10,13-pentaoxa-16-aza-cyclooctadecane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / Et₂NH / methanol / 16 h / 70 °C

2.1: KOH / methanol; tetrahydrofuran / 1 h / 20 °C

2.2: H₂SO₄ / methanol; tetrahydrofuran / 0 - 20 °C

2.3: 49 percent / NH₄OAc; AcOH / 1 h / 100 °C

With potassium hydroxide; diethylamine; In tetrahydrofuran; methanol; 1.1: Henry addition / 2.1: Nef reaction;
DOI:10.1021/jo062506r