Technology Process of (E)-1-benzyloxy-6-tert-butyldimethylsilyloxy-4-<(2,4-dimethoxy-3-methylphenyl)oxy>-2-hexene
There total 7 articles about (E)-1-benzyloxy-6-tert-butyldimethylsilyloxy-4-<(2,4-dimethoxy-3-methylphenyl)oxy>-2-hexene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: LiAlH4, AlCl3 / diethyl ether / 1.) 0 deg C to RT, 30 min; 2.) 2 h
2: pyridinium chlorochromate, Celite / CH2Cl2 / 3 h
3: trimethyl borate, Zn / tetrahydrofuran / 6 h
4: LiAlH4 / diethyl ether / 0.25 h
5: 80 percent / 4-dimethylaminopyridine, triethylamine / CH2Cl2 / 16 h / Ambient temperature
6: nBu3P, diethylazodicarboxylate / diethyl ether / 1.) -25 deg C, 10 min; 2.) 1 h, -25 deg C four times; 3.) 2 h
With
dmap; lithium aluminium tetrahydride; aluminium trichloride; Trimethyl borate; tributylphosphine; Celite; triethylamine; pyridinium chlorochromate; zinc; diethylazodicarboxylate;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00299a022
- Guidance literature:
-
Multi-step reaction with 4 steps
1: trimethyl borate, Zn / tetrahydrofuran / 6 h
2: LiAlH4 / diethyl ether / 0.25 h
3: 80 percent / 4-dimethylaminopyridine, triethylamine / CH2Cl2 / 16 h / Ambient temperature
4: nBu3P, diethylazodicarboxylate / diethyl ether / 1.) -25 deg C, 10 min; 2.) 1 h, -25 deg C four times; 3.) 2 h
With
dmap; lithium aluminium tetrahydride; Trimethyl borate; tributylphosphine; triethylamine; zinc; diethylazodicarboxylate;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00299a022
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridinium chlorochromate, Celite / CH2Cl2 / 3 h
2: trimethyl borate, Zn / tetrahydrofuran / 6 h
3: LiAlH4 / diethyl ether / 0.25 h
4: 80 percent / 4-dimethylaminopyridine, triethylamine / CH2Cl2 / 16 h / Ambient temperature
5: nBu3P, diethylazodicarboxylate / diethyl ether / 1.) -25 deg C, 10 min; 2.) 1 h, -25 deg C four times; 3.) 2 h
With
dmap; lithium aluminium tetrahydride; Trimethyl borate; tributylphosphine; Celite; triethylamine; pyridinium chlorochromate; zinc; diethylazodicarboxylate;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00299a022
