tert-butyl (R,R,R)-2-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]cyclohexane-1-carboxylate

Base Information

Chemical Name:tert-butyl (R,R,R)-2-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]cyclohexane-1-carboxylate
CAS No.:1619924-91-2
Molecular Formula:C₂₈H₃₉NO₄
Molecular Weight:453.622
Hs Code.:

Synonyms:tert-butyl (R,R,R)-2-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]cyclohexane-1-carboxylate

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Chemical Property of tert-butyl (R,R,R)-2-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]cyclohexane-1-carboxylate

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Technology Process of tert-butyl (R,R,R)-2-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]cyclohexane-1-carboxylate

There total 5 articles about tert-butyl (R,R,R)-2-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]cyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1619924-90-1
tert-butyl (R,R)-3-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]-7-chloroheptanoate

: 1619924-91-2
tert-butyl (R,R,R)-2-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]cyclohexane-1-carboxylate

Guidance literature:: tert-butyl (R,R)-3-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]-7-chloroheptanoate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With 1-iodo-3-(tert-butyldimethylsilyloxy)propane; In tetrahydrofuran; at -78 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c4cc02135e

Reference yield:

: 117471-84-8
1,1-dimethylethyl (E)-7-hydroxyhept-2-enoate

: 1619924-91-2
tert-butyl (R,R,R)-2-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]cyclohexane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; triethylamine; tetrachloromethane / acetonitrile / 24 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 12 h / -78 - 20 °C / Inert atmosphere

With tetrachloromethane; n-butyllithium; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1039/c4cc02135e

Reference yield:

: 542-28-9,26354-94-9
3,4,5,6-tetrahydro-2H-pyran-2-one

: 1619924-91-2
tert-butyl (R,R,R)-2-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]cyclohexane-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride; n-butyllithium / tetrahydrofuran / 16 h / -78 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; triethylamine; tetrachloromethane / acetonitrile / 24 h / Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 12 h / -78 - 20 °C / Inert atmosphere

With tetrachloromethane; n-butyllithium; diisobutylaluminium hydride; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1039/c4cc02135e