N-<(4-oxo-4H-5,6-dihydrocyclopentathiophene-5-yl)acetyl>-4-(p-fluorobenzoyl)piperidine

Base Information

• Chemical Name: N-<(4-oxo-4H-5,6-dihydrocyclopentathiophene-5-yl)acetyl>-4-(p-fluorobenzoyl)piperidine
• CAS No.: 240403-63-8
• Molecular Formula: C₂₁H₂₀FNO₃S
• Molecular Weight: 385.459

Synonyms:N-<(4-oxo-4H-5,6-dihydrocyclopentathiophene-5-yl)acetyl>-4-(p-fluorobenzoyl)piperidine

Chemical Property of N-<(4-oxo-4H-5,6-dihydrocyclopentathiophene-5-yl)acetyl>-4-(p-fluorobenzoyl)piperidine

Chemical Property:

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Technology Process of N-<(4-oxo-4H-5,6-dihydrocyclopentathiophene-5-yl)acetyl>-4-(p-fluorobenzoyl)piperidine

There total 3 articles about N-<(4-oxo-4H-5,6-dihydrocyclopentathiophene-5-yl)acetyl>-4-(p-fluorobenzoyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(4-fluorophenyl)-piperidin-4-ylmethanone (56346-57-7) + 4-oxo-4H-5,6-dihydrocyclopentathiophene-5-ylacetic acid (176639-50-2) → N-<(4-oxo-4H-5,6-dihydrocyclopentathiophene-5-yl)acetyl>-4-(p-fluorobenzoyl)piperidine (240403-63-8)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;

DOI:10.1021/jm981094e

Reference yield:

5,6-dihydro-<6H>-cyclopenta--thiophene-4-one (5650-51-1) → N-<(4-oxo-4H-5,6-dihydrocyclopentathiophene-5-yl)acetyl>-4-(p-fluorobenzoyl)piperidine (240403-63-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) LDA / 1.) -70 deg C

2: KOH / ethanol

3: 78 percent / HOBt, DCC / CH₂Cl₂ / Ambient temperature

With potassium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In ethanol; dichloromethane;

DOI:10.1021/jm981094e

Reference yield:

(4-Oxo-5,6-dihydro-4H-cyclopenta[b]thiophen-5-yl)-acetic acid ethyl ester (176639-49-9) → N-<(4-oxo-4H-5,6-dihydrocyclopentathiophene-5-yl)acetyl>-4-(p-fluorobenzoyl)piperidine (240403-63-8)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / ethanol

2: 78 percent / HOBt, DCC / CH₂Cl₂ / Ambient temperature

With potassium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1021/jm981094e

upstream raw materials:

(4-fluorophenyl)-piperidin-4-ylmethanone

4-oxo-4H-5,6-dihydrocyclopentathiophene-5-ylacetic acid

5,6-dihydro-<6H>-cyclopenta--thiophene-4-one

(4-Oxo-5,6-dihydro-4H-cyclopenta[b]thiophen-5-yl)-acetic acid ethyl ester

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