4-{2-[1-(3-Amino-propylcarbamoyl)-ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (2-hydroxy-ethyl)-amide

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Chemical Name:4-{2-[1-(3-Amino-propylcarbamoyl)-ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (2-hydroxy-ethyl)-amide
CAS No.:1332760-73-2
Molecular Formula:C₂₂H₂₇FN₆O₄S
Molecular Weight:490.559
Hs Code.:

Synonyms:4-{2-[1-(3-Amino-propylcarbamoyl)-ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (2-hydroxy-ethyl)-amide

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Chemical Property of 4-{2-[1-(3-Amino-propylcarbamoyl)-ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (2-hydroxy-ethyl)-amide

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Technology Process of 4-{2-[1-(3-Amino-propylcarbamoyl)-ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (2-hydroxy-ethyl)-amide

There total 10 articles about 4-{2-[1-(3-Amino-propylcarbamoyl)-ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (2-hydroxy-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₅FN₆O₆S

: 1332760-73-2
4-{2-[1-(3-Amino-propylcarbamoyl)-ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (2-hydroxy-ethyl)-amide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 832113-96-9
methyl 4-chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylate

: 1332760-73-2
4-{2-[1-(3-Amino-propylcarbamoyl)-ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (2-hydroxy-ethyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / 1,4-dioxane / 0.25 h / 140 °C / Microwave irradiation; Sealed tube

2.1: caesium carbonate / acetonitrile / 2 h / 60 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 0.25 h / 20 °C

4.2: 48 h / 50 °C

5.1: sodium hydroxide; methanol / tetrahydrofuran / 40 °C

5.2: 20 °C

6.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h / 20 °C

6.2: 20 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With methanol; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 53981-24-1
2-amino-5-fluorophenol

: 1332760-73-2
4-{2-[1-(3-Amino-propylcarbamoyl)-ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (2-hydroxy-ethyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / 1,4-dioxane / 0.25 h / 140 °C / Microwave irradiation; Sealed tube

2.1: caesium carbonate / acetonitrile / 2 h / 60 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 0.25 h / 20 °C

4.2: 48 h / 50 °C

5.1: sodium hydroxide; methanol / tetrahydrofuran / 40 °C

5.2: 20 °C

6.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h / 20 °C

6.2: 20 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With methanol; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;