Cyclobutanecarboxylic acid, 3-amino-2,2-dimethyl-, cis- (9CI)

Base Information

• Chemical Name: Cyclobutanecarboxylic acid, 3-amino-2,2-dimethyl-, cis- (9CI)
• CAS No.: 92772-95-7
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.186
• Mol file: 92772-95-7.mol

Synonyms:Cyclobutanecarboxylicacid, 3-amino-2,2-dimethyl-, cis- (9CI); Cyclobutanecarboxylic acid, 3-amino-2,2-dimethyl-,cis-(?à)-

Chemical Property of Cyclobutanecarboxylic acid, 3-amino-2,2-dimethyl-, cis- (9CI)

Chemical Property:

• PSA: 63.32000
• LogP: 1.14470

Purity/Quality:

97% ^*data from raw suppliers

(1S,3R)-3-amino-2,2-dimethylcyclobutane-1-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclobutanecarboxylic acid, 3-amino-2,2-dimethyl-, cis- (9CI)

There total 12 articles about Cyclobutanecarboxylic acid, 3-amino-2,2-dimethyl-, cis- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1R,3S)-3-(((benzyloxy)carbonyl)amino)-2,2-dimethylcyclobutan-1-carboxylic acid (1017279-76-3) → (1R,3S)-3-amino-2,2-dimethylcyclobutanecarboxylic acid (865799-12-8,92772-95-7)

Guidance literature:

With 20% palladium hydroxide-activated charcoal; hydrogen; In methanol; under 3800.26 Torr;

DOI:10.1021/jm4008505

Reference yield: 83.0%

Methyl (1S,3R)-(+)-3-acetamido-2,2-dimethylcyclobutanecarboxylate (308287-84-5) → (1S,3R)-3-amino-2,2-dimethylcyclobutan-1-carboxylic acid (527751-18-4,92772-95-7)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1016/S0957-4166(02)00823-6

Reference yield: 74.0%

(1R,3S)-3-acetamido-2,2-dimethylcyclobutane-carboxylic acid (865799-11-7) → (1R,3S)-3-amino-2,2-dimethylcyclobutanecarboxylic acid (865799-12-8,92772-95-7)

Guidance literature:

(1R,3S)-3-acetamido-2,2-dimethylcyclobutane-carboxylic acid; With hydrogenchloride; for 36h; Heating;

With Dowex 50W; In water;

DOI:10.1016/j.tetasy.2005.06.030

upstream raw materials:

(1S,3R)-3-[(tert-butoxycarbonyl)amino]-2,2-dimethylcyclobutane-1-carboxylic acid

Methyl (1S,3R)-(+)-3-acetamido-2,2-dimethylcyclobutanecarboxylate

methyl (1S,3R)-3-acetyl-2,2-dimethylcyclobutanecarboxylate

(+)-cis-pinononoic acid