2-amino-2-(2'-benzyloxy-4'-methoxycarbonyl)phenylacetonitrile

Base Information

• Chemical Name: 2-amino-2-(2'-benzyloxy-4'-methoxycarbonyl)phenylacetonitrile
• CAS No.: 357953-45-8
• Molecular Formula: C₁₇H₁₆N₂O₃
• Molecular Weight: 296.326
• Mol file: 357953-45-8.mol

Synonyms:2-amino-2-(2'-benzyloxy-4'-methoxycarbonyl)phenylacetonitrile

Chemical Property of 2-amino-2-(2'-benzyloxy-4'-methoxycarbonyl)phenylacetonitrile

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-amino-2-(2'-benzyloxy-4'-methoxycarbonyl)phenylacetonitrile

There total 2 articles about 2-amino-2-(2'-benzyloxy-4'-methoxycarbonyl)phenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

sodium cyanide (143-33-9,25596-52-5) + methyl 3-(benzyloxy)-4-formylbenzoate → 2-amino-2-(2'-benzyloxy-4'-methoxycarbonyl)phenylacetonitrile (357953-45-8)

Guidance literature:

With ammonia; ammonium chloride; In methanol; water; at 20 ℃;

DOI:10.1016/S0968-0896(00)00345-X

Reference yield:

methyl 4-formyl-3-hydroxybenzoate (24589-98-8) → 2-amino-2-(2'-benzyloxy-4'-methoxycarbonyl)phenylacetonitrile (357953-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / potassium carbonate / dimethylformamide / 2 h / 20 °C

2: 73 percent / ammonia; NH₄Cl / methanol; H₂O / 20 °C

With ammonia; potassium carbonate; ammonium chloride; In methanol; water; N,N-dimethyl-formamide; 2: Strecker reaction;

DOI:10.1016/S0968-0896(00)00345-X

Reference yield:

2-amino-2-(2'-benzyloxy-4'-methoxycarbonyl)phenylacetonitrile (357953-45-8) → 4-(amino-carboxy-methyl)-3-hydroxy-benzoic acid; hydrochloride

Guidance literature:

With hydrogenchloride; at 115 ℃; for 16h;

DOI:10.1016/S0968-0896(00)00345-X

upstream raw materials:

sodium cyanide

methyl 4-formyl-3-hydroxybenzoate