Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3S,4S)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-chroman-3-yloxy]-tetrahydro-pyran-3-yl ester

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Chemical Name:Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3S,4S)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-chroman-3-yloxy]-tetrahydro-pyran-3-yl ester
CAS No.:908855-85-6
Molecular Formula:C₅₃H₈₈O₁₆Si₄
Molecular Weight:1093.61
Hs Code.:

Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3S,4S)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-chroman-3-yloxy]-tetrahydro-pyran-3-yl ester

Synonyms:Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3S,4S)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-chroman-3-yloxy]-tetrahydro-pyran-3-yl ester

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Chemical Property of Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3S,4S)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-chroman-3-yloxy]-tetrahydro-pyran-3-yl ester

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Technology Process of Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3S,4S)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-chroman-3-yloxy]-tetrahydro-pyran-3-yl ester

There total 5 articles about Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3S,4S)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-chroman-3-yloxy]-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 908855-84-5
Acetic acid (2R,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3S)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-chroman-3-yloxy]-tetrahydro-pyran-3-yl ester

: Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3R)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-4-oxo-chroman-3-yloxy]-tetrahydro-pyran-3-yl ester

: 908855-85-6
Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3S,4S)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-chroman-3-yloxy]-tetrahydro-pyran-3-yl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; water; at 20 ℃; for 3h;
DOI:10.1021/ol0614976

Reference yield:

: 908855-83-4
Acetic acid (2R,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3S)-5,7-bis-benzyloxy-2-(3,4-bis-benzyloxy-phenyl)-chroman-3-yloxy]-tetrahydro-pyran-3-yl ester

: 908855-85-6
Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3S,4S)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-chroman-3-yloxy]-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd(OH)2/C / ethyl acetate; methanol / 2 h / 20 °C / 760 Torr

2: 1.02 g / imidazole; DMAP / dimethylformamide / 3 h / 65 °C

3: 74 percent / DDQ / methanol; H₂O / 3 h / 20 °C

With 1H-imidazole; dmap; hydrogen; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol0614976

Reference yield:

: 20728-73-8
5,7,3',4'-tetra-O-benzyl-(+)-catechin

: 908855-85-6
Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3S,4S)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-chroman-3-yloxy]-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / TMSOTf / CH₂Cl₂ / 2 h / -40 °C

2: H₂ / Pd(OH)2/C / ethyl acetate; methanol / 2 h / 20 °C / 760 Torr

3: 1.02 g / imidazole; DMAP / dimethylformamide / 3 h / 65 °C

4: 74 percent / DDQ / methanol; H₂O / 3 h / 20 °C

With 1H-imidazole; dmap; trimethylsilyl trifluoromethanesulfonate; hydrogen; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol0614976