Technology Process of 1-[1-benzyloxy-(1S)-ethyl]-2-tert-butyldimethylsilyloxymethyl-(1S,2S)-hexyl alcohol
There total 4 articles about 1-[1-benzyloxy-(1S)-ethyl]-2-tert-butyldimethylsilyloxymethyl-(1S,2S)-hexyl alcohol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 85 percent / DIBAL-H / toluene; CH2Cl2 / 0.5 h / -20 °C
2.1: 71 percent / (-)-diisopropyl tartrate; titanium isopropoxide; cumene hydroperoxide / 4 Angstroem molecular sieves / CH2Cl2 / 12 h / -20 °C
3.1: copper(I) iodide / diethyl ether; hexane / 0.5 h / -20 °C
3.2: 80 percent / diethyl ether; hexane / 1 h / -20 °C
4.1: 83 percent / imidazole / CH2Cl2 / 1 h / 20 °C
With
1H-imidazole; titanium(IV) isopropylate; copper(l) iodide; (-)-diisopropyl tartrate; Cumene hydroperoxide; diisobutylaluminium hydride;
4 A molecular sieve;
In
diethyl ether; hexane; dichloromethane; toluene;
2.1: Sharpless asymmetric epoxidation;
DOI:10.1055/s-2004-829173
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 71 percent / (-)-diisopropyl tartrate; titanium isopropoxide; cumene hydroperoxide / 4 Angstroem molecular sieves / CH2Cl2 / 12 h / -20 °C
2.1: copper(I) iodide / diethyl ether; hexane / 0.5 h / -20 °C
2.2: 80 percent / diethyl ether; hexane / 1 h / -20 °C
3.1: 83 percent / imidazole / CH2Cl2 / 1 h / 20 °C
With
1H-imidazole; titanium(IV) isopropylate; copper(l) iodide; (-)-diisopropyl tartrate; Cumene hydroperoxide;
4 A molecular sieve;
In
diethyl ether; hexane; dichloromethane;
1.1: Sharpless asymmetric epoxidation;
DOI:10.1055/s-2004-829173
