4-acetyl-5-carbmethoxy-1-(dibenzylamino)-6H-7-oxa-3-oxo-2-phenyl-2-azabicyclo<2.2.1>hept-5-ene

Base Information

Chemical Name:4-acetyl-5-carbmethoxy-1-(dibenzylamino)-6H-7-oxa-3-oxo-2-phenyl-2-azabicyclo<2.2.1>hept-5-ene
CAS No.:130935-33-0
Molecular Formula:C₂₉H₂₆N₂O₅
Molecular Weight:482.536
Hs Code.:

Synonyms:4-acetyl-5-carbmethoxy-1-(dibenzylamino)-6H-7-oxa-3-oxo-2-phenyl-2-azabicyclo<2.2.1>hept-5-ene

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Chemical Property of 4-acetyl-5-carbmethoxy-1-(dibenzylamino)-6H-7-oxa-3-oxo-2-phenyl-2-azabicyclo<2.2.1>hept-5-ene

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Technology Process of 4-acetyl-5-carbmethoxy-1-(dibenzylamino)-6H-7-oxa-3-oxo-2-phenyl-2-azabicyclo<2.2.1>hept-5-ene

There total 5 articles about 4-acetyl-5-carbmethoxy-1-(dibenzylamino)-6H-7-oxa-3-oxo-2-phenyl-2-azabicyclo<2.2.1>hept-5-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 130935-30-7
N'-(diazoacetoacetyl)-N'-phenyl-N,N-bis(phenylmethyl)urea

: 922-67-8
propynoic acid methyl ester

: 130935-32-9
4-acetyl-6-carbomethoxy-1-(dibenzylamino)-5H-7-oxa-3-oxo-2-phenyl-2-azabicyclo<2.2.1>hept-5-ene

: 130935-33-0
4-acetyl-5-carbmethoxy-1-(dibenzylamino)-6H-7-oxa-3-oxo-2-phenyl-2-azabicyclo<2.2.1>hept-5-ene

Guidance literature:: rhodium(II) octanoate; In benzene; at 25 ℃; for 4.5h;
DOI:10.1021/jo00002a058

Reference yield:

: 53693-57-5
N'-phenyl-N,N-bis(phenylmethyl)urea

: 130935-33-0
4-acetyl-5-carbmethoxy-1-(dibenzylamino)-6H-7-oxa-3-oxo-2-phenyl-2-azabicyclo<2.2.1>hept-5-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) aq. n-butyllithium / 1.) THF, hexane, -78 degC 2.) THF

2: 75 percent / mesyl azide, Et₃N / acetonitrile / 25 °C

3: 25 percent / rhodium(II) octanoate / benzene / 4.5 h / 25 °C

With n-butyllithium; triethylamine; Methanesulfonyl azide; rhodium(II) octanoate; In acetonitrile; benzene;
DOI:10.1021/jo00002a058

Reference yield:

: 130935-37-4
N'-acetoacetyl-N'-phenyl-N,N-bis(phenylmethyl)urea

: 130935-33-0
4-acetyl-5-carbmethoxy-1-(dibenzylamino)-6H-7-oxa-3-oxo-2-phenyl-2-azabicyclo<2.2.1>hept-5-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / mesyl azide, Et₃N / acetonitrile / 25 °C

2: 25 percent / rhodium(II) octanoate / benzene / 4.5 h / 25 °C

With triethylamine; Methanesulfonyl azide; rhodium(II) octanoate; In acetonitrile; benzene;
DOI:10.1021/jo00002a058