N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxy-butyl)-amino]-pent-4-enyl-1,2,5,6-tetrahydropyridine

Base Information

Chemical Name:N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxy-butyl)-amino]-pent-4-enyl-1,2,5,6-tetrahydropyridine
CAS No.:309248-71-3
Molecular Formula:C₃₄H₄₆N₂O₆
Molecular Weight:578.749
Hs Code.:

Synonyms:N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxy-butyl)-amino]-pent-4-enyl-1,2,5,6-tetrahydropyridine

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Chemical Property of N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxy-butyl)-amino]-pent-4-enyl-1,2,5,6-tetrahydropyridine

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Technology Process of N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxy-butyl)-amino]-pent-4-enyl-1,2,5,6-tetrahydropyridine

There total 6 articles about N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxy-butyl)-amino]-pent-4-enyl-1,2,5,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 75-11-6
diiodomethane

: 309248-67-7
3-[N-benzyloxycarbonyl-(4,4-diethoxybutyl)amino]-4-(N-benzyloxycarbonyl-1,2,5,6-tetrahydropyridin-2-yl)butyraldehyde

: 309248-71-3
N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxy-butyl)-amino]-pent-4-enyl-1,2,5,6-tetrahydropyridine

Guidance literature:: With chromium dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; for 1h;
DOI:10.1021/ja001688i

Reference yield:

: (4,4-Diethoxy-butyl)-{(R)-1-[(S)-1-(1,2,5,6-tetrahydro-pyridin-2-yl)methyl]-allyl}-amine

: 309248-71-3
N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxy-butyl)-amino]-pent-4-enyl-1,2,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 813 mg / dimethylformamide / 0.17 h / 20 °C

2: 76 percent / oxygen; PdCl₂; CuCl / dimethylformamide; H₂O / 6 h

3: 65 percent / CrCl₂; DMF / tetrahydrofuran / 1 h

With chromium dichloride; oxygen; N,N-dimethyl-formamide; copper(l) chloride; palladium dichloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; 3: Takai olefination;
DOI:10.1021/ja001688i

Reference yield:

: 309248-35-9
methyl (1R,4S)-4-(but-3-enyl-N-nosylamino)cyclopent-2-enyl carbonate

: 309248-71-3
N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxy-butyl)-amino]-pent-4-enyl-1,2,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 2.49 g / tetrahydrofuran / 3 h / 20 °C

2: 79 percent / Cl₂[P(cyclohexyl)3]2Ru=CHPh; C₂H₄ / CH₂Cl₂ / 48 h / 35 °C

3: K₂CO₃; thiophenol / dimethylformamide / 30 h / 70 °C

4: 813 mg / dimethylformamide / 0.17 h / 20 °C

5: 76 percent / oxygen; PdCl₂; CuCl / dimethylformamide; H₂O / 6 h

6: 65 percent / CrCl₂; DMF / tetrahydrofuran / 1 h

With chromium dichloride; Grubbs catalyst first generation; ethene; oxygen; potassium carbonate; thiophenol; N,N-dimethyl-formamide; copper(l) chloride; palladium dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 6: Takai olefination;
DOI:10.1021/ja001688i