Technology Process of N-cyclohexyl-N-methyl-7-(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxyheptanamide
There total 11 articles about N-cyclohexyl-N-methyl-7-(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxyheptanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: aq. Na2CO3 / tetrahydrofuran / 1 h / Ambient temperature
2: 1.) AcONa / ethanol / 0.5 h
3: NaBH3CN / ethanol / 3 h
4: H2 / 10percent Pd/C / ethanol
5: 2.) conc. aq. NH3 / 1.) EtOH, RT, overnight, 2.) EtOH, RT, 30 min
With
ammonium hydroxide; hydrogen; sodium acetate; sodium cyanoborohydride; sodium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol;
DOI:10.1021/jm00385a012
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 94 percent / K2CO3 / dimethylformamide
2: 61 percent / aq. KOH
3: oxalyl chloride / benzene; dimethylformamide / 0.5 h
4: aq. Na2CO3 / tetrahydrofuran / 1 h / Ambient temperature
5: 1.) AcONa / ethanol / 0.5 h
6: NaBH3CN / ethanol / 3 h
7: H2 / 10percent Pd/C / ethanol
8: 2.) conc. aq. NH3 / 1.) EtOH, RT, overnight, 2.) EtOH, RT, 30 min
With
potassium hydroxide; ammonium hydroxide; oxalyl dichloride; hydrogen; sodium acetate; sodium cyanoborohydride; sodium carbonate; potassium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00385a012
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 94 percent / K2CO3 / dimethylformamide
2: 61 percent / aq. KOH
3: oxalyl chloride / benzene; dimethylformamide / 0.5 h
4: aq. Na2CO3 / tetrahydrofuran / 1 h / Ambient temperature
5: 1.) AcONa / ethanol / 0.5 h
6: NaBH3CN / ethanol / 3 h
7: H2 / 10percent Pd/C / ethanol
8: 2.) conc. aq. NH3 / 1.) EtOH, RT, overnight, 2.) EtOH, RT, 30 min
With
potassium hydroxide; ammonium hydroxide; oxalyl dichloride; hydrogen; sodium acetate; sodium cyanoborohydride; sodium carbonate; potassium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00385a012