Technology Process of ethyl 4-(4-(2-((6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl)amino)ethyl)phenoxy)butanoate
There total 7 articles about ethyl 4-(4-(2-((6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl)amino)ethyl)phenoxy)butanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
acetone;
at 20 ℃;
for 25h;
Inert atmosphere;
Reflux;
DOI:10.1016/j.bmcl.2013.03.070
- Guidance literature:
-
Multi-step reaction with 5 steps
1: ammonium hydroxide / acetonitrile / 5.5 h / 55 °C
2: bromine; sodium acetate trihydrate / tetrahydrofuran; water; methanol / 0.5 h / -10 - 20 °C
3: caesium carbonate / N,N-dimethyl-formamide / 20 h / 80 °C
4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 23 h / 145 °C
5: potassium carbonate / acetone / 25 h / 20 °C / Inert atmosphere; Reflux
With
ammonium hydroxide; bromine; sodium acetate trihydrate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2013.03.070
- Guidance literature:
-
Multi-step reaction with 4 steps
1: bromine; sodium acetate trihydrate / tetrahydrofuran; water; methanol / 0.5 h / -10 - 20 °C
2: caesium carbonate / N,N-dimethyl-formamide / 20 h / 80 °C
3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 23 h / 145 °C
4: potassium carbonate / acetone / 25 h / 20 °C / Inert atmosphere; Reflux
With
bromine; sodium acetate trihydrate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2013.03.070