ethyl 4-(4-(2-((6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl)amino)ethyl)phenoxy)butanoate

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Chemical Name:ethyl 4-(4-(2-((6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl)amino)ethyl)phenoxy)butanoate
CAS No.:1436428-67-9
Molecular Formula:C₂₂H₂₇N₉O₃
Molecular Weight:465.515
Hs Code.:

Synonyms:ethyl 4-(4-(2-((6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl)amino)ethyl)phenoxy)butanoate

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Chemical Property of ethyl 4-(4-(2-((6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl)amino)ethyl)phenoxy)butanoate

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Technology Process of ethyl 4-(4-(2-((6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl)amino)ethyl)phenoxy)butanoate

There total 7 articles about ethyl 4-(4-(2-((6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl)amino)ethyl)phenoxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 2969-81-5
Ethyl 4-bromobutyrate

: 1436428-51-1
4-(2-((6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl)amino)ethyl)phenol?

: 1436428-67-9
ethyl 4-(4-(2-((6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl)amino)ethyl)phenoxy)butanoate

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 25h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmcl.2013.03.070

Reference yield:

: 2382-10-7
2,6-dichloro-9-methyl-9H-purine

: 1436428-67-9
ethyl 4-(4-(2-((6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl)amino)ethyl)phenoxy)butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium hydroxide / acetonitrile / 5.5 h / 55 °C

2: bromine; sodium acetate trihydrate / tetrahydrofuran; water; methanol / 0.5 h / -10 - 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 20 h / 80 °C

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 23 h / 145 °C

5: potassium carbonate / acetone / 25 h / 20 °C / Inert atmosphere; Reflux

With ammonium hydroxide; bromine; sodium acetate trihydrate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2013.03.070

Reference yield:

: 7013-21-0
2-Chloro-9-methyladenine

: 1436428-67-9
ethyl 4-(4-(2-((6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl)amino)ethyl)phenoxy)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; sodium acetate trihydrate / tetrahydrofuran; water; methanol / 0.5 h / -10 - 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 20 h / 80 °C

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 23 h / 145 °C

4: potassium carbonate / acetone / 25 h / 20 °C / Inert atmosphere; Reflux

With bromine; sodium acetate trihydrate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2013.03.070