2382-10-7

Basic information

• Product Name: 2,6-DICHLORO-9-METHYL-9H-PURINE
• Synonyms: 2,6-DICHLORO-9-METHYL-9H-PURINE;2,6-Dichloro-9-Methylpurine;9-Methyl-2,6-dichloropurine
• CAS NO: 2382-10-7
• Molecular Formula: C₆H₄Cl₂N₄
• Molecular Weight: 203.03
• Mol File: 2382-10-7.mol

Chemical Properties

• Melting Point: 152-153℃
• Boiling Point: 307.2°C at 760 mmHg
• Flash Point: 139.6°C
• Appearance: /
• Density: 1.76
• Vapor Pressure: 0.000733mmHg at 25°C
• Refractive Index: 1.76
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.90±0.10(Predicted)
• CAS DataBase Reference: 2,6-DICHLORO-9-METHYL-9H-PURINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DICHLORO-9-METHYL-9H-PURINE(2382-10-7)
• EPA Substance Registry System: 2,6-DICHLORO-9-METHYL-9H-PURINE(2382-10-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 2382-10-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,6-DICHLORO-9-METHYL-9H-PURINE is used as a reagent for the synthesis of highly selective inhibitors of PI3K-δ (Phosphoinositide 3-kinase delta). These inhibitors are crucial in the treatment of inflammatory diseases, particularly those related to leukocytes, which are white blood cells that play a vital role in the immune system. By targeting PI3K-δ, these inhibitors can help regulate the immune response and alleviate the symptoms of various leukocyte-related illnesses.

InChI:InChI=1/C6H4Cl2N4/c1-12-2-9-3-4(7)10-6(8)11-5(3)12/h2H,1H3

Upstream product

• 74-87-3 methylene chloride 
• 5451-40-1 2,6 dichloropurine 
• 74-83-9 methyl bromide 
• 69-89-6 xanthin 
• 5451-40-1 2,6-dichloro-7H-purine 
• 74-88-4 methyl iodide 
• 5451-40-1 2,6-dichloropurine 
• 1198-33-0 9-methylxanthine 

Downstream Products

• 101622-53-1 2-chloro-6-benzylamino-9-methylpurine 
• 30720-65-1 2,6-Diamino-9-methylpurine 
• 925254-29-1 2-chloro-N-cyclohexyl-9-methyl-9H-purin-6-amine 
• 1062592-41-9 (2-chloro-9-methyl-9H-purin-6-yl)-(4-chloro-phenyl)-amine 
• 1055926-73-2 1,1-dimethylethyl 2-(2-chloro-9-methyl-9H-purin-6-yl)-2-cyclo-hexyl-hydrazine-carboxylate 
• 1063332-85-3 (4-bromo-phenyl)-(2-chloro-9-methyl-9H-purin-6-yl)-amine 
• 1055925-12-6 N'-(2-cyano-9-methyl-9H-purin-6-yl)-N'-cyclohexyl-4-({4-[(4-methyl-1-piperazinyl)carbonyl]-1-piperidinyl}methyl)benzohydrazide trifluoroacetate 
• 1055924-89-4 N'-(2-cyano-9-methyl-9H-purin-6-yl)-N'-(cyclopentylmethyl)-4-({4-[(1-methyl-3-piperidinyl)methyl]-1-piperazinyl}methyl)benzohydrazide trifluoroacetate 
• 1055924-87-2 N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-(cyclopentylmethyl)-4-({4-[(1-methyl-4-piperidinyl)methyl]-1-piperazinyl}methyl)benzohydrazide trifluoroacetate 
• 1055925-09-1 N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclohexyl-4-({4-[(1-methyl-4-piperidinyl)methyl]-1-piperazinyl}methyl)-benzohydrazide trifluoroacetate 
• 1055925-07-9 N',N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclohexyl-4-{[4-(4-methyl-1-piperazinyl)-1-piperidinyl]methyl}benzohydrazide trifluoroacetate 

Relevant articles and documents

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