methyl 11α,15(S)-bis<<(1,1-dimethylethyl)diphenylsilyl>oxy>-6,9α-epoxy-5(S)-fluoroprosta-6,13(E)-dien-1-oate

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Chemical Name:methyl 11α,15(S)-bis<<(1,1-dimethylethyl)diphenylsilyl>oxy>-6,9α-epoxy-5(S)-fluoroprosta-6,13(E)-dien-1-oate
CAS No.:105662-11-1
Molecular Formula:C₅₃H₆₉FO₅Si₂
Molecular Weight:861.297
Hs Code.:

Synonyms:methyl 11α,15(S)-bis<<(1,1-dimethylethyl)diphenylsilyl>oxy>-6,9α-epoxy-5(S)-fluoroprosta-6,13(E)-dien-1-oate

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Chemical Property of methyl 11α,15(S)-bis<<(1,1-dimethylethyl)diphenylsilyl>oxy>-6,9α-epoxy-5(S)-fluoroprosta-6,13(E)-dien-1-oate

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Technology Process of methyl 11α,15(S)-bis<<(1,1-dimethylethyl)diphenylsilyl>oxy>-6,9α-epoxy-5(S)-fluoroprosta-6,13(E)-dien-1-oate

There total 9 articles about methyl 11α,15(S)-bis<<(1,1-dimethylethyl)diphenylsilyl>oxy>-6,9α-epoxy-5(S)-fluoroprosta-6,13(E)-dien-1-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 107082-06-4
(S)-5-{(2R,3aR,4R,5R,6aS)-5-(tert-Butyl-diphenyl-silanyloxy)-4-[(E)-(S)-3-(tert-butyl-diphenyl-silanyloxy)-oct-1-enyl]-2-methoxy-hexahydro-cyclopenta[b]furan-2-yl}-5-fluoro-pentanoic acid methyl ester

: 105662-11-1
methyl 11α,15(S)-bis<<(1,1-dimethylethyl)diphenylsilyl>oxy>-6,9α-epoxy-5(S)-fluoroprosta-6,13(E)-dien-1-oate

Guidance literature:: With α-picoline; magnesium triflate; In xylene; for 1.5h; Heating;
DOI:10.1021/jo00382a003

Reference yield: 7.0%

: 105604-43-1
Methyl 11α,15S-bis[[(1,1-dimethylethyl)-diphenylsilyl]oxy]-6,9α-epoxy-5S-fluoro-6S-methoxyprost-13E-en-1-oate

: 105662-11-1
methyl 11α,15(S)-bis<<(1,1-dimethylethyl)diphenylsilyl>oxy>-6,9α-epoxy-5(S)-fluoroprosta-6,13(E)-dien-1-oate

: 107133-45-9
methyl 11α,15(S)-bis<<(1,1-dimethylethyl)diphenylsilyl>oxy>-6,9α-epoxy-5-fluoroprosta-5(Z),13(E)-dien-1-oate

Guidance literature:: With 2,6-dimethylpyridine; magnesium triflate; for 0.166667h; Heating;
DOI:10.1021/jo00382a003

Reference yield:

: 33854-16-9
(+)-prostaglandin F_2α

: 105662-11-1
methyl 11α,15(S)-bis<<(1,1-dimethylethyl)diphenylsilyl>oxy>-6,9α-epoxy-5(S)-fluoroprosta-6,13(E)-dien-1-oate

Guidance literature:: Multi-step reaction with 3 steps

2: 23 percent / K₂CO₃, FClO₃

3: 74 percent / 2,6-lutidine, magnesium triflate, tert-butyltoluene / 0.17 h / Heating

With 2,6-dimethylpyridine; perchloryl fluoride; potassium carbonate; magnesium triflate;
DOI:10.1021/jo00382a003