4-CHLOROBENZENECARBALDEHYDE N-(3-OXO-3,4-DIHYDRO-2-QUINOXALINYL)HYDRAZONE

Base Information

• Chemical Name: 4-CHLOROBENZENECARBALDEHYDE N-(3-OXO-3,4-DIHYDRO-2-QUINOXALINYL)HYDRAZONE
• CAS No.: 129227-26-5
• Molecular Formula: C₁₅H₁₁ClN₄O
• Molecular Weight: 298.732
• Mol file: 129227-26-5.mol

Synonyms:3-{N'-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-hydrazino}-1H-quinoxalin-2-one

Chemical Property of 4-CHLOROBENZENECARBALDEHYDE N-(3-OXO-3,4-DIHYDRO-2-QUINOXALINYL)HYDRAZONE

Chemical Property:

• Melting Point: 256-258 °C(Solv: ethanol (64-17-5))
• PKA: 9.58±0.10(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)

Purity/Quality:

4-Chlorobenzenecarbaldehyde N-(3-oxo-3,4-dihydro-2-quinoxalinyl)hydrazone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-CHLOROBENZENECARBALDEHYDE N-(3-OXO-3,4-DIHYDRO-2-QUINOXALINYL)HYDRAZONE

There total 3 articles about 4-CHLOROBENZENECARBALDEHYDE N-(3-OXO-3,4-DIHYDRO-2-QUINOXALINYL)HYDRAZONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-hydrazineylidene-3,4-dihydroquinoxalin-2(1H)-one (31595-63-8) + 4-chlorobenzaldehyde (104-88-1) → 3-{N'-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-hydrazino}-1H-quinoxalin-2-one (129227-26-5)

Guidance literature:

In ethanol; for 5h; Heating;

DOI:10.1002/jhet.5570270339

Reference yield:

1,2-diamino-benzene (95-54-5) → 3-{N'-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-hydrazino}-1H-quinoxalin-2-one (129227-26-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / water / 4 h / Reflux

2: hydrazine hydrate / 2 h / Reflux

3: ethanol / 2 h / Reflux

With hydrogenchloride; hydrazine hydrate; In ethanol; water;

DOI:10.1016/j.bioorg.2019.102932

Reference yield:

quinoxaline-2,3-dione (15804-19-0,6287-20-3) → 3-{N'-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-hydrazino}-1H-quinoxalin-2-one (129227-26-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / 2 h / Reflux

2: ethanol / 2 h / Reflux

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.bioorg.2019.102932

upstream raw materials:

3-hydrazineylidene-3,4-dihydroquinoxalin-2(1H)-one

4-chlorobenzaldehyde

1,2-diamino-benzene

quinoxaline-2,3-dione

Downstream raw materials:

1-(4-chlorophenyl)-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one

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