5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid (4-sulfamoylphenylcarbamoyl)methyl ester

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Chemical Name:5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid (4-sulfamoylphenylcarbamoyl)methyl ester
CAS No.:1421318-24-2
Molecular Formula:C₄₆H₃₆N₈O₉S
Molecular Weight:876.906
Hs Code.:

Synonyms:5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid (4-sulfamoylphenylcarbamoyl)methyl ester

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Chemical Property of 5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid (4-sulfamoylphenylcarbamoyl)methyl ester

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Technology Process of 5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid (4-sulfamoylphenylcarbamoyl)methyl ester

There total 13 articles about 5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid (4-sulfamoylphenylcarbamoyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 14949-01-0
2-chloro-N-(4-sulfamoylphenyl)acetamide

: 1421318-30-0
C₃₈H₂₈N₆O₆

: 1421318-24-2
5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid (4-sulfamoylphenylcarbamoyl)methyl ester

Guidance literature:: C₃₈H₂₈N₆O₆; With potassium carbonate; In N,N-dimethyl-formamide; for 0.5h;

2-chloro-N-(4-sulfamoylphenyl)acetamide; In N,N-dimethyl-formamide; for 20h;
DOI:10.1039/c3cc38251f

Reference yield:

: 6427-66-3
4-azidobenzoic acid

: 1421318-24-2
5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid (4-sulfamoylphenylcarbamoyl)methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / Reflux

2.1: sodium hydroxide / methanol / 3 h / 50 °C

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0.08 h

3.2: 48 h / 40 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 h

6.1: sodium hydroxide / methanol / 6 h / 50 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

7.2: 20 h

With potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3cc38251f

Reference yield:

: 1421318-27-5
5-(4-azido-benzoylamino)isophthalic acid monomethyl ester

: 1421318-24-2
5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid (4-sulfamoylphenylcarbamoyl)methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0.08 h

1.2: 48 h / 40 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 h

4.1: sodium hydroxide / methanol / 6 h / 50 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

5.2: 20 h

With potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3cc38251f