1-(4-chlorobenzyl)-8-(1-hydroxyethyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione

Base Information

Chemical Name:1-(4-chlorobenzyl)-8-(1-hydroxyethyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
CAS No.:1073239-43-6
Molecular Formula:C₁₇H₁₉ClN₄O₃
Molecular Weight:362.816
Hs Code.:

Synonyms:1-(4-chlorobenzyl)-8-(1-hydroxyethyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-chlorobenzyl)-8-(1-hydroxyethyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione

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Technology Process of 1-(4-chlorobenzyl)-8-(1-hydroxyethyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione

There total 4 articles about 1-(4-chlorobenzyl)-8-(1-hydroxyethyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 849585-22-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6
LACTIC ACID

: 1073239-44-7
5,6-diamino-3-(4-chlorobenzyl)-1-propylpyrimidine-2,4(1H,3H)-dione

: 1073239-43-6
1-(4-chlorobenzyl)-8-(1-hydroxyethyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione

Guidance literature:: LACTIC ACID; 5,6-diamino-3-(4-chlorobenzyl)-1-propylpyrimidine-2,4(1H,3H)-dione; In 1,4-dioxane; at 100 ℃; for 1h; Microwaves;

With sodium hydroxide; In 1,4-dioxane; ethanol; water; for 1.5h; Heating / reflux;

With acetic acid; In 1,4-dioxane; ethanol; water;

Reference yield:

: 53681-47-3
6-amino-1-propyl-1H-pyrimidine-2,4-dione

: 1073239-43-6
1-(4-chlorobenzyl)-8-(1-hydroxyethyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide dimethyl acetal / N,N-dimethyl-formamide / 3.5 h / 40 °C

1.2: 73 h / 40 - 80 °C

1.3: 1 h / 120 °C / Microwaves

2.1: acetic acid; sodium nitrite / water / 1 h / 80 °C

3.1: sodium dithionite; ammonia / water; acetonitrile / 1.08 h / 80 °C

4.1: 1,4-dioxane / 1 h / 100 °C / Microwaves

4.2: 1.5 h / Heating / reflux

With sodium dithionite; ammonia; acetic acid; N,N-dimethyl-formamide dimethyl acetal; sodium nitrite; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1073239-46-9
6-amino-3-(4-chlorobenzyl)-1-propylpyrimidine-2,4(1H,3H)-dione

: 1073239-43-6
1-(4-chlorobenzyl)-8-(1-hydroxyethyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; sodium nitrite / water / 1 h / 80 °C

2.1: sodium dithionite; ammonia / water; acetonitrile / 1.08 h / 80 °C

3.1: 1,4-dioxane / 1 h / 100 °C / Microwaves

3.2: 1.5 h / Heating / reflux

With sodium dithionite; ammonia; acetic acid; sodium nitrite; In 1,4-dioxane; water; acetonitrile;