(3'R,5'R)-1-<5'-<(benzyloxy)methyl>tetrahydrofuran-3'-yl>-pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:(3'R,5'R)-1-<5'-<(benzyloxy)methyl>tetrahydrofuran-3'-yl>-pyrimidine-2,4(1H,3H)-dione
CAS No.:132813-68-4
Molecular Formula:C₁₆H₁₈N₂O₄
Molecular Weight:302.33
Hs Code.:

Synonyms:(3'R,5'R)-1-<5'-<(benzyloxy)methyl>tetrahydrofuran-3'-yl>-pyrimidine-2,4(1H,3H)-dione

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Chemical Property of (3'R,5'R)-1-<5'-<(benzyloxy)methyl>tetrahydrofuran-3'-yl>-pyrimidine-2,4(1H,3H)-dione

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Technology Process of (3'R,5'R)-1-<5'-<(benzyloxy)methyl>tetrahydrofuran-3'-yl>-pyrimidine-2,4(1H,3H)-dione

There total 10 articles about (3'R,5'R)-1-<5'-<(benzyloxy)methyl>tetrahydrofuran-3'-yl>-pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 142941-41-1
(2R,4S)-2-<(benzyloxy)methyl>-4-<(methylsulfonyl)oxy>tetrahydrofuran

: 66-22-8
4-Hydroxy-1H-pyrimidin-2-one

: 132813-68-4
(3'R,5'R)-1-<5'-<(benzyloxy)methyl>tetrahydrofuran-3'-yl>-pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 85 ℃;

Reference yield:

: 32785-98-1
3-deoxy-1,2:5,6-di-O-isopropylidene-β-D-lyxo-hexose

: 132813-68-4
(3'R,5'R)-1-<5'-<(benzyloxy)methyl>tetrahydrofuran-3'-yl>-pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 8 steps

1: HCl / methanol; H₂O

2: NaIO₄ / methanol; H₂O / 0.25 h

3: NaBH₄ / methanol / 0.42 h

4: 1) NaH, 2) Bu₄NI / 1) THF, 20 min, 2) THF, 50 deg C, 1.5 h

5: 94 percent / Dowex 50W-X₈(H) resin / 18 h / Heating

6: 87 percent / Et₃SiH, BF₃*Et₂O / CH₂Cl₂ / 44 h / Ambient temperature

7: 95 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0.5 h

8: 55 percent / K₂CO₃ / dimethylsulfoxide / 85 °C

With hydrogenchloride; triethylsilane; dmap; sodium tetrahydroborate; sodium periodate; Dowex 50W-X₈(H) resin; boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; In methanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 78038-33-2
3S,5R-5-<(benzyloxy)methyl>tetrahydrofuran-3-ol

: 132813-68-4
(3'R,5'R)-1-<5'-<(benzyloxy)methyl>tetrahydrofuran-3'-yl>-pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0.5 h

2: 55 percent / K₂CO₃ / dimethylsulfoxide / 85 °C

With dmap; potassium carbonate; In dichloromethane; dimethyl sulfoxide;