4-nitro-N-(4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-ynyl)-benzenesulfonamide

Base Information

• Chemical Name: 4-nitro-N-(4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-ynyl)-benzenesulfonamide
• CAS No.: 457071-62-4
• Molecular Formula: C₂₄H₂₄N₂O₆S
• Molecular Weight: 468.53

Synonyms:4-nitro-N-(4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-ynyl)-benzenesulfonamide

Chemical Property of 4-nitro-N-(4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-ynyl)-benzenesulfonamide

Chemical Property:

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Technology Process of 4-nitro-N-(4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-ynyl)-benzenesulfonamide

There total 7 articles about 4-nitro-N-(4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-ynyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-Nitrobenzenesulfonyl chloride (98-74-8) + 4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-ynylamine (457071-61-3) → 4-nitro-N-(4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-ynyl)-benzenesulfonamide (457071-62-4)

Guidance literature:

With triethylamine;

DOI:10.1016/S0960-894X(02)00029-X

Reference yield:

4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-yn-1-ol (457071-58-8) → 4-nitro-N-(4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-ynyl)-benzenesulfonamide (457071-62-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / NEt₃

2: 80 percent / NaN₃ / dimethylformamide

3: 85 percent / PPh₃ / H₂O; tetrahydrofuran

4: 78 percent / NEt₃

With sodium azide; triethylamine; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00029-X

Reference yield:

2-{3-[2-(4-azido-but-1-ynyl)-phenyl]-prop-2-ynyloxy}-tetrahydro-pyran (457071-60-2) → 4-nitro-N-(4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-ynyl)-benzenesulfonamide (457071-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / PPh₃ / H₂O; tetrahydrofuran

2: 78 percent / NEt₃

With triethylamine; triphenylphosphine; In tetrahydrofuran; water;

DOI:10.1016/S0960-894X(02)00029-X

upstream raw materials:

4-Nitrobenzenesulfonyl chloride

4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-ynylamine

2-bromo-1-(1-hydroxy-3-butyn-4-yl)benzene

4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-yn-1-ol

Downstream raw materials:

C₃₁H₂₂N₂O₆S₂

C₃₁H₂₂N₂O₆S₂

C₃₁H₂₂N₂O₆S₂

C₃₁H₂₂N₂O₄S₂

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