2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-phenylbenzo[d]isoxazol-5-yl)benzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-phenylbenzo[d]isoxazol-5-yl)benzofuran-3-carboxamide
CAS No.:1426845-02-4
Molecular Formula:C₃₁H₂₄FN₃O₅S
Molecular Weight:569.613
Hs Code.:

Synonyms:2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-phenylbenzo[d]isoxazol-5-yl)benzofuran-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-phenylbenzo[d]isoxazol-5-yl)benzofuran-3-carboxamide

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Technology Process of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-phenylbenzo[d]isoxazol-5-yl)benzofuran-3-carboxamide

There total 4 articles about 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-phenylbenzo[d]isoxazol-5-yl)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 402914-15-2
5-bromo-3-phenylbenzo[d]isoxazole

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

: 1426845-02-4
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-phenylbenzo[d]isoxazol-5-yl)benzofuran-3-carboxamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate; In 1,4-dioxane; water; at 100 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1523-17-7
4-bromophenyl benzoate

: 1426845-02-4
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-phenylbenzo[d]isoxazol-5-yl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride / 3 h / 150 °C

2: pyridine; hydroxylamine hydrochloride / ethanol / 16 h / Reflux

3: triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 20 °C

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

With pyridine; aluminum (III) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate; hydroxylamine hydrochloride; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 55082-33-2
5-bromo-2-hydroxybenzophenone

: 1426845-02-4
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-phenylbenzo[d]isoxazol-5-yl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; hydroxylamine hydrochloride / ethanol / 16 h / Reflux

2: triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate; hydroxylamine hydrochloride; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; ethanol; dichloromethane; water;