1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-phenylurea

Base Information

Chemical Name:1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-phenylurea
CAS No.:1442473-46-2
Molecular Formula:C₂₃H₁₉F₂N₅O₂
Molecular Weight:435.433
Hs Code.:

Synonyms:1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-phenylurea

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Chemical Property of 1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-phenylurea

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Technology Process of 1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-phenylurea

There total 13 articles about 1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1442473-44-0
7-amino-3-(5-amino-2,4-difluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

: 103-71-9
phenyl isocyanate

: 1442473-46-2
1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-phenylurea

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1442470-76-9
7-(4-methoxybenzylamino)-3-(5-amino-2,4-difluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

: 1442473-46-2
1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / trifluoroacetic acid / 60 °C

2: triethylamine / dichloromethane / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; trifluoroacetic acid;

Reference yield:

: 959162-97-1
6-chloro-4-ethylamino-nicotinic acid ethyl ester

: 1442473-46-2
1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / water; tetrahydrofuran / 1 h / -50 - 0 °C

2: manganese(IV) oxide / dichloromethane / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 90 °C

4: acetic acid / 130 °C

5: trifluoroacetic acid / trifluoroacetic acid / 60 °C

6: triethylamine / dichloromethane / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; trifluoroacetic acid;