N-acetyl-N-{3-[2,4-difluoro-5-(3-phenyl-ureido)-phenyl]-1-ethyl-2-oxo-1,2-dihydro[1,6]naphthyridin-7-yl}-acetamide

Base Information

• Chemical Name: N-acetyl-N-{3-[2,4-difluoro-5-(3-phenyl-ureido)-phenyl]-1-ethyl-2-oxo-1,2-dihydro[1,6]naphthyridin-7-yl}-acetamide
• CAS No.: 1442473-48-4
• Molecular Formula: C₂₇H₂₃F₂N₅O₄
• Molecular Weight: 519.508
• Mol file: 1442473-48-4.mol

Synonyms:N-acetyl-N-{3-[2,4-difluoro-5-(3-phenyl-ureido)-phenyl]-1-ethyl-2-oxo-1,2-dihydro[1,6]naphthyridin-7-yl}-acetamide

Chemical Property of N-acetyl-N-{3-[2,4-difluoro-5-(3-phenyl-ureido)-phenyl]-1-ethyl-2-oxo-1,2-dihydro[1,6]naphthyridin-7-yl}-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-acetyl-N-{3-[2,4-difluoro-5-(3-phenyl-ureido)-phenyl]-1-ethyl-2-oxo-1,2-dihydro[1,6]naphthyridin-7-yl}-acetamide

There total 14 articles about N-acetyl-N-{3-[2,4-difluoro-5-(3-phenyl-ureido)-phenyl]-1-ethyl-2-oxo-1,2-dihydro[1,6]naphthyridin-7-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-phenylurea (1442473-46-2) + acetyl chloride (75-36-5) → N-acetyl-N-{3-[2,4-difluoro-5-(3-phenyl-ureido)-phenyl]-1-ethyl-2-oxo-1,2-dihydro[1,6]naphthyridin-7-yl}-acetamide (1442473-48-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

7-(4-methoxybenzylamino)-3-(5-amino-2,4-difluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one (1442470-76-9) → N-acetyl-N-{3-[2,4-difluoro-5-(3-phenyl-ureido)-phenyl]-1-ethyl-2-oxo-1,2-dihydro[1,6]naphthyridin-7-yl}-acetamide (1442473-48-4)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / trifluoroacetic acid / 60 °C

2: triethylamine / dichloromethane / 20 °C

3: triethylamine / tetrahydrofuran / 2 h / 20 °C

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; trifluoroacetic acid;

Reference yield:

6-chloro-4-ethylamino-nicotinic acid ethyl ester (959162-97-1) → N-acetyl-N-{3-[2,4-difluoro-5-(3-phenyl-ureido)-phenyl]-1-ethyl-2-oxo-1,2-dihydro[1,6]naphthyridin-7-yl}-acetamide (1442473-48-4)

Guidance literature:

Multi-step reaction with 7 steps

1: lithium aluminium tetrahydride / water; tetrahydrofuran / 1 h / -50 - 0 °C

2: manganese(IV) oxide / dichloromethane / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 90 °C

4: acetic acid / 130 °C

5: trifluoroacetic acid / trifluoroacetic acid / 60 °C

6: triethylamine / dichloromethane / 20 °C

7: triethylamine / tetrahydrofuran / 2 h / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; trifluoroacetic acid;

upstream raw materials:

7-amino-3-(5-amino-2,4-difluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-phenylurea

acetyl chloride

7-(4-methoxybenzylamino)-3-(5-amino-2,4-difluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

Downstream raw materials:

1-(5-(7-acetamido-1-ethyl-2-oxo-1,2-dihydro[1,6]naphthyridin-3-yl)-2,4-difluorophenyl)-3-phenylurea