(3R,4S,5R)-5-(benzoyloxymethyl)-3-fluoro-3,4-dimethyltetrahydrofuran-2,4-diyl diacetate

Base Information

Chemical Name:(3R,4S,5R)-5-(benzoyloxymethyl)-3-fluoro-3,4-dimethyltetrahydrofuran-2,4-diyl diacetate
CAS No.:1187433-95-9
Molecular Formula:C₁₈H₂₁FO₇
Molecular Weight:368.359
Hs Code.:

Synonyms:(3R,4S,5R)-5-(benzoyloxymethyl)-3-fluoro-3,4-dimethyltetrahydrofuran-2,4-diyl diacetate

Suppliers and Price of (3R,4S,5R)-5-(benzoyloxymethyl)-3-fluoro-3,4-dimethyltetrahydrofuran-2,4-diyl diacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S,5R)-5-(benzoyloxymethyl)-3-fluoro-3,4-dimethyltetrahydrofuran-2,4-diyl diacetate

Chemical Property:

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Technology Process of (3R,4S,5R)-5-(benzoyloxymethyl)-3-fluoro-3,4-dimethyltetrahydrofuran-2,4-diyl diacetate

There total 1 articles about (3R,4S,5R)-5-(benzoyloxymethyl)-3-fluoro-3,4-dimethyltetrahydrofuran-2,4-diyl diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.27%

: 1248344-72-0
((2R,3S,4R)-4-fluoro-3-hydroxy-5-methoxy-3,4-dimethyltetrahydrofuran-2-yl)methyl benzoate

: 108-24-7
acetic anhydride

: 1187433-95-9
(3R,4S,5R)-5-(benzoyloxymethyl)-3-fluoro-3,4-dimethyltetrahydrofuran-2,4-diyl diacetate

Guidance literature:: With sulfuric acid; acetic acid; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2010.07.017

Reference yield: 30.0%

: 1187433-95-9
(3R,4S,5R)-5-(benzoyloxymethyl)-3-fluoro-3,4-dimethyltetrahydrofuran-2,4-diyl diacetate

: 10310-21-1
2-Amino-6-chloropurin

: 1187434-23-6
((2R,3S,4R,5R)-3-acetoxy-5-(2-amino-6-chloro-9H-purin-9-yl)-4-fluoro-3,4-dimethyltetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: 2-Amino-6-chloropurin; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; at 20 ℃; Reflux; Inert atmosphere;

(3R,4S,5R)-5-(benzoyloxymethyl)-3-fluoro-3,4-dimethyltetrahydrofuran-2,4-diyl diacetate; With tin(IV) chloride; In acetonitrile; at 0 ℃; Inert atmosphere; Reflux;

With sodium hydrogencarbonate; In water; acetonitrile; Inert atmosphere;
DOI:10.1016/j.bmc.2010.07.017

Reference yield:

: 1187433-95-9
(3R,4S,5R)-5-(benzoyloxymethyl)-3-fluoro-3,4-dimethyltetrahydrofuran-2,4-diyl diacetate

: 87-42-3,111055-92-6
6-chloro-7H-purine

: 1187433-96-0
((2R,3S,4R,5R)-3-acetoxy-5-(6-chloro-9H-purin-9-yl)-4-fluoro-3,4-dimethyltetrahydrofuran-2-yl)methyl benzoate

: 1187434-00-9
((2R,3S,4R,5S)-3-acetoxy-5-(6-chloro-9H-purin-9-yl)-4-fluoro-3,4-dimethyltetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: 6-chloro-7H-purine; With trimethylsilyl trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 ℃;

(3R,4S,5R)-5-(benzoyloxymethyl)-3-fluoro-3,4-dimethyltetrahydrofuran-2,4-diyl diacetate; In acetonitrile; at 0 - 65 ℃;