Phenylalanine, 2-methoxy--alpha--methyl--bta--oxo-, methyl ester

Base Information

• Chemical Name: Phenylalanine, 2-methoxy--alpha--methyl--bta--oxo-, methyl ester
• CAS No.: 96994-42-2
• Molecular Formula: C12H15 N O4
• Molecular Weight: 237.2518
• Mol file: 96994-42-2.mol

Synonyms:Phenylalanine, 2-methoxy--alpha--methyl--bta--oxo-, methyl ester

Chemical Property of Phenylalanine, 2-methoxy--alpha--methyl--bta--oxo-, methyl ester

Chemical Property:

• PSA: 78.62000
• LogP: 1.46860

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenylalanine, 2-methoxy--alpha--methyl--bta--oxo-, methyl ester

There total 12 articles about Phenylalanine, 2-methoxy--alpha--methyl--bta--oxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 3-(2-methoxyphenyl)-2-methyl-2H-azirine-2-carboxylate (96994-41-1) → methyl 2-(2-methoxybenzoyl)alaninate (96994-42-2)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1039/c39850000218

Reference yield:

(1,2-benzisoxazol-3-yl)(phenylthio)acetic acid (82897-91-4) → methyl 2-(2-methoxybenzoyl)alaninate (96994-42-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 76 percent / conc. sulphuric acid / 20 h / Heating

2: 70 percent / sodium metaperiodate / H₂O; methanol / 18 h / 50 °C

3: 84 percent / NaOH / 5 h / other reagent

4: 74 percent / 60percent sodium hydride / toluene / 2 h / Ambient temperature

5: 70 percent / t-BuOK / dimethylformamide / 0.5 h / Ambient temperature

6: 92 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) room temp., 30 min

7: 97 percent / 10percent HCl / methanol / 3 h / Heating

With hydrogenchloride; sodium hydroxide; sodium periodate; potassium tert-butylate; sodium hydride; sulfuric acid; In methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

(1,2-benzisoxazol-3-yl)(p-tolylthio)acetic acid (117343-45-0) → methyl 2-(2-methoxybenzoyl)alaninate (96994-42-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 73 percent / conc. sulphuric acid / 15 h / Heating

2: 65 percent / m-chloroperbenzoic acid / CHCl₃ / 1 h / Ambient temperature

3: 86 percent / MeONa / 2 h / other reagent

4: 74 percent / 60percent sodium hydride / toluene / 2 h / Ambient temperature

5: 70 percent / t-BuOK / dimethylformamide / 0.5 h / Ambient temperature

6: 92 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) room temp., 30 min

7: 97 percent / 10percent HCl / methanol / 3 h / Heating

With hydrogenchloride; potassium tert-butylate; sodium methylate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; sulfuric acid; In methanol; chloroform; N,N-dimethyl-formamide; toluene;

upstream raw materials:

methyl 3-(2-methoxyphenyl)-2-methyl-2H-azirine-2-carboxylate

methyl 3-(2-hydroxyphenyl)-2-methyl-2H-azirine-2-carboxylate

methyl (1,2-benzisoxazol-3-yl)methylacetate

(1,2-benzisoxazol-3-yl)(phenylthio)acetic acid

Downstream raw materials:

2-Acetylamino-3-(2-methoxy-phenyl)-2-methyl-3-oxo-propionic acid methyl ester

Refernces

• 1、 Ueda, Shozo,Naruto, Shunsuke,Yoshida, Toyokichi,Sawayama, Tadahiro,Uno, Hitoshi. "Novel Base-induced Ring Transformation of 1,2-Benzisoxazole-3-acetic Acid Esters into 2H-Azirines or Benzofurans". . p. 218 - 219. Retrieved 2007/10/02.