6-(4-bromophenyl)-5-(4-(trifluoromethyl)phenyl)thiazolo[3,2-b]-1,2,4-triazole

Base Information

Chemical Name:6-(4-bromophenyl)-5-(4-(trifluoromethyl)phenyl)thiazolo[3,2-b]-1,2,4-triazole
CAS No.:1423120-83-5
Molecular Formula:C₁₇H₉BrF₃N₃S
Molecular Weight:424.244
Hs Code.:

Synonyms:6-(4-bromophenyl)-5-(4-(trifluoromethyl)phenyl)thiazolo[3,2-b]-1,2,4-triazole

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Chemical Property of 6-(4-bromophenyl)-5-(4-(trifluoromethyl)phenyl)thiazolo[3,2-b]-1,2,4-triazole

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Technology Process of 6-(4-bromophenyl)-5-(4-(trifluoromethyl)phenyl)thiazolo[3,2-b]-1,2,4-triazole

There total 3 articles about 6-(4-bromophenyl)-5-(4-(trifluoromethyl)phenyl)thiazolo[3,2-b]-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 37664-01-0
6-(4-bromophenyl)thiazolo[3,2-b]-1,2,4-triazole

: 455-13-0
4-Iodobenzotrifluoride

: 1423120-83-5
6-(4-bromophenyl)-5-(4-(trifluoromethyl)phenyl)thiazolo[3,2-b]-1,2,4-triazole

Guidance literature:: With copper acetylacetonate; potassium tert-butylate; In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide; at 20 - 120 ℃; for 12.08h; regioselective reaction; Inert atmosphere;
DOI:10.1039/c2ob27326h

Reference yield:

: 99-73-0,132309-76-3
para-bromophenacyl bromide

: 1423120-83-5
6-(4-bromophenyl)-5-(4-(trifluoromethyl)phenyl)thiazolo[3,2-b]-1,2,4-triazole

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 14 h / 20 °C / Reflux

2: polyphosphoric acid / 3 h / 160 °C

3: copper acetylacetonate; potassium tert-butylate / N,N-dimethyl-formamide; 5,5-dimethyl-1,3-cyclohexadiene / 12.08 h / 20 - 120 °C / Inert atmosphere

With copper acetylacetonate; potassium tert-butylate; In 5,5-dimethyl-1,3-cyclohexadiene; ethanol; N,N-dimethyl-formamide;
DOI:10.1039/c2ob27326h

Reference yield:

: 37664-32-7
2-(1H-1,2,4-triazol-3-ylthio)-1-(4-bromophenyl) ethanone

: 1423120-83-5
6-(4-bromophenyl)-5-(4-(trifluoromethyl)phenyl)thiazolo[3,2-b]-1,2,4-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: polyphosphoric acid / 3 h / 160 °C

2: copper acetylacetonate; potassium tert-butylate / N,N-dimethyl-formamide; 5,5-dimethyl-1,3-cyclohexadiene / 12.08 h / 20 - 120 °C / Inert atmosphere

With copper acetylacetonate; potassium tert-butylate; In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;
DOI:10.1039/c2ob27326h