1,1-dioxo-5-piperidin-4-yl-1λ6-[1,2,5]thiadiazolidine-2-benzyl carboxylate trifluoroacetic acid salt

Base Information

• Chemical Name: 1,1-dioxo-5-piperidin-4-yl-1λ6-[1,2,5]thiadiazolidine-2-benzyl carboxylate trifluoroacetic acid salt
• CAS No.: 1374856-80-0
• Molecular Formula: C₂HF₃O₂*C₁₅H₂₁N₃O₄S
• Molecular Weight: 453.439

Synonyms:1,1-dioxo-5-piperidin-4-yl-1λ6-[1,2,5]thiadiazolidine-2-benzyl carboxylate trifluoroacetic acid salt

Chemical Property of 1,1-dioxo-5-piperidin-4-yl-1λ6-[1,2,5]thiadiazolidine-2-benzyl carboxylate trifluoroacetic acid salt

Chemical Property:

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Technology Process of 1,1-dioxo-5-piperidin-4-yl-1λ6-[1,2,5]thiadiazolidine-2-benzyl carboxylate trifluoroacetic acid salt

There total 3 articles about 1,1-dioxo-5-piperidin-4-yl-1λ6-[1,2,5]thiadiazolidine-2-benzyl carboxylate trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-(5-benzyloxycarbonyl-1,1-dioxo-1λ6-[1,2,5]thiadiazolidin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester (1374856-78-6) + trifluoroacetic acid (76-05-1) → 1,1-dioxo-5-piperidin-4-yl-1λ6-[1,2,5]thiadiazolidine-2-benzyl carboxylate trifluoroacetic acid salt (1374856-80-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2012.03.049

Reference yield:

tert-butyl 4-[(2-hydroxyethyl)amino]piperidine-1-carboxylate (701298-37-5) → 1,1-dioxo-5-piperidin-4-yl-1λ6-[1,2,5]thiadiazolidine-2-benzyl carboxylate trifluoroacetic acid salt (1374856-80-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 16 h / Reflux

2: dichloromethane / 16 h / 20 °C

In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2012.03.049

Reference yield:

N-[[[(benzyloxy)carbonyl]azanide]sulfonyl]-N,N-diethylethylammonium (439585-11-2) → 1,1-dioxo-5-piperidin-4-yl-1λ6-[1,2,5]thiadiazolidine-2-benzyl carboxylate trifluoroacetic acid salt (1374856-80-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 16 h / Reflux

2: dichloromethane / 16 h / 20 °C

In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2012.03.049

upstream raw materials:

tert-butyl 4-[(2-hydroxyethyl)amino]piperidine-1-carboxylate

4-(5-benzyloxycarbonyl-1,1-dioxo-1λ6-[1,2,5]thiadiazolidin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester

trifluoroacetic acid

N-[[[(benzyloxy)carbonyl]azanide]sulfonyl]-N,N-diethylethylammonium

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