tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-bromopyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-cyclopropylcarbamate

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Chemical Name:tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-bromopyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-cyclopropylcarbamate
CAS No.:1349734-93-5
Molecular Formula:C₃₂H₄₀BrN₅O₇
Molecular Weight:686.603
Hs Code.:

Synonyms:tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-bromopyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-cyclopropylcarbamate

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Chemical Property of tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-bromopyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-cyclopropylcarbamate

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Technology Process of tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-bromopyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-cyclopropylcarbamate

There total 5 articles about tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-bromopyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-cyclopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1349735-23-4
tert-butyl N-cyclopropyl-N-[[4-[(E)-hydroxyiminomethyl]phenyl]methyl]carbamate

: 1232423-55-0
tert-butyl N-(5-bromo-3-ethynyl-pyrazin-2-yl)-N-tert-butoxycarbonyl-carbamate

: 1349734-93-5
tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-bromopyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-cyclopropylcarbamate

Guidance literature:: tert-butyl N-cyclopropyl-N-[[4-[(E)-hydroxyiminomethyl]phenyl]methyl]carbamate; With N-chloro-succinimide; In N,N-dimethyl-formamide; at 55 ℃; for 0.5h;

tert-butyl N-(5-bromo-3-ethynyl-pyrazin-2-yl)-N-tert-butoxycarbonyl-carbamate; With triethylamine; In N,N-dimethyl-formamide; at 20 - 65 ℃; for 2.75h;

Reference yield:

: 875781-41-2
5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

: 1349734-93-5
tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-bromopyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-cyclopropylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / dichloromethane / 20 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 0.75 h / 75 °C

2.2: 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 1.75 h / 20 - 65 °C

4.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / fluorobenzene / 1 h / 90 °C

5.1: N,N-dimethyl-formamide / 1 h / 20 °C

5.2: 1 h / 20 °C

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium carbonate; triethylamine; In fluorobenzene; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1225062-32-7
tert-butyl N-tert-butoxycarbonyl-N-[5-bromo-3-((trimethylsilyl)ethyynyl)pyrazin-2-yl]carbamate

: 1349734-93-5
tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-bromopyrazin-2-yl]isoxazol-3-yl]phenyl]methyl]-N-cyclopropylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 0.75 h / 75 °C

1.2: 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 1.75 h / 20 - 65 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / fluorobenzene / 1 h / 90 °C

4.1: N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 1 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium carbonate; triethylamine; In fluorobenzene; N,N-dimethyl-formamide;