[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)hypoxanthine

Base Information

Chemical Name:[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)hypoxanthine
CAS No.:503173-78-2
Molecular Formula:C₂₆H₂₂N₄O₈
Molecular Weight:523.428
Hs Code.:

Synonyms:[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)hypoxanthine

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Chemical Property of [ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)hypoxanthine

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Technology Process of [ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)hypoxanthine

There total 5 articles about [ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)hypoxanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 503173-75-9
¹³C₅-1′, 2 ′-di-O-acetyl-3 ′ ,5 ′-di-O-benzoyl-β-D-ribofuranose

: 503173-78-2
[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)hypoxanthine

Guidance literature:: 1,7-dihydro-6H-purin-6-one; With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; Heating;

¹³C₅-1′, 2 ′-di-O-acetyl-3 ′ ,5 ′-di-O-benzoyl-β-D-ribofuranose; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; for 2.5h; Heating;
DOI:10.1016/S0040-4020(02)01246-2

Reference yield:

: 126590-65-6
<1,2,3,4,5,6-13C6>-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose

: 503173-78-2
[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)hypoxanthine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 94 percent / pyridinium dichromate; acetic anhydride / CH₂Cl₂ / 1.5 h / Heating

2.1: H₅IO₆ / ethyl acetate / 2 h / 20 °C

2.2: 80 percent / NaBH₄ / ethanol / 0.5 h

3.1: 95 percent / pyridine / 3 h / 20 °C

4.1: 87 percent / H₂SO₄; AcOH / 20 °C

5.1: HMDS; (NH₄)2SO₄ / Heating

5.2: 86 percent / TMSOTf / CH₂Cl₂ / 2.5 h / Heating

With pyridine; ammonium sulfate; dipyridinium dichromate; sulfuric acid; acetic anhydride; acetic acid; periodic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(02)01246-2

Reference yield:

: 503173-73-7
[glu-13C6]-1,2:5,6-di-O-isopropylidene-3-oxo-α-D-glucofuranose

: 503173-78-2
[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)hypoxanthine

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₅IO₆ / ethyl acetate / 2 h / 20 °C

1.2: 80 percent / NaBH₄ / ethanol / 0.5 h

2.1: 95 percent / pyridine / 3 h / 20 °C

3.1: 87 percent / H₂SO₄; AcOH / 20 °C

4.1: HMDS; (NH₄)2SO₄ / Heating

4.2: 86 percent / TMSOTf / CH₂Cl₂ / 2.5 h / Heating

With pyridine; ammonium sulfate; sulfuric acid; acetic acid; periodic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In ethyl acetate;
DOI:10.1016/S0040-4020(02)01246-2