Chemical Property of CID 790
Chemical Property:
- Appearance/Colour:White to off-white powder
- Vapor Pressure:0.0148mmHg at 25°C
- Melting Point:250 °C
- Refractive Index:1.902
- Boiling Point:533.428 °C at 760 mmHg
- PKA:8.7(at 25℃)
- Flash Point:276.407 °C
- PSA：74.43000
- Density:1.892 g/cm3
- LogP:-0.35380
- Storage Temp.:2-8°C
- Solubility.:1 M NaOH: 25 mg/mL
- Water Solubility.:practically insoluble
- XLogP3:-1.1
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:0
- Exact Mass:136.03851076
- Heavy Atom Count:10
- Complexity:190
- Purity/Quality:
-
99%, *data from raw suppliers
Hypoxanthine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
36/37/38-22-40
- Safety Statements:
22-24/25-37/39-26-36
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:C1=NC2=C(N1)C(=O)N=CN2
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Description
Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid. It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia. Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.
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Uses
A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies. Hypoxanthine, is used as a marker for energy perturbation in hypoxia/ ischemia. The compound has been used in studies as in indicator, along with uric acid and allantoin , of in vivo free radical reactions. It has been also used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol ? (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus. It is also used as a pharmaceutical intermediate.
