4-{(R)-2-[4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidin-1-yl]-1-methyl-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

Base Information

Chemical Name:4-{(R)-2-[4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidin-1-yl]-1-methyl-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one
CAS No.:1266245-41-3
Molecular Formula:C₂₀H₂₂ClF₃N₄O₃
Molecular Weight:458.868
Hs Code.:

Synonyms:4-{(R)-2-[4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidin-1-yl]-1-methyl-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

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Chemical Property of 4-{(R)-2-[4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidin-1-yl]-1-methyl-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

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Technology Process of 4-{(R)-2-[4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidin-1-yl]-1-methyl-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

There total 5 articles about 4-{(R)-2-[4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidin-1-yl]-1-methyl-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1266244-86-3
trifluoro-methanesulphonic acid 2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl ester

: 1266244-66-9
(R)-2-amino-1-[4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidin-1-yl]-propan-1-one

: 1266245-41-3
4-{(R)-2-[4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidin-1-yl]-1-methyl-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

Guidance literature:: With triethylamine; In acetonitrile; at 85 ℃; for 3h;

Reference yield:

: 933-76-6
4,5-dichloro-2-methyl-3(2H)-pyridazinone

: 1266245-41-3
4-{(R)-2-[4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidin-1-yl]-1-methyl-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine; hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 48 h / 20 °C / 5250.53 Torr

3.1: potassium hydroxide; water / 24 h / 100 °C

3.2: pH 1

4.1: triethylamine / dichloromethane / -9 - -1 °C / Inert atmosphere

5.1: triethylamine / acetonitrile / 3 h / 85 °C

With potassium tert-butylate; water; hydrogen; triethylamine; potassium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 77541-59-4
5-chloro-4-methoxy-2-methyl-3(2H)-pyridazinone

: 1266245-41-3
4-{(R)-2-[4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidin-1-yl]-1-methyl-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 48 h / 20 °C / 5250.53 Torr

2.1: potassium hydroxide; water / 24 h / 100 °C

2.2: pH 1

3.1: triethylamine / dichloromethane / -9 - -1 °C / Inert atmosphere

4.1: triethylamine / acetonitrile / 3 h / 85 °C

With water; hydrogen; triethylamine; potassium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; acetonitrile;