933-76-6

Basic information

• Product Name: 4,5-DICHLORO-2-METHYLPYRIDAZIN-3-ONE
• Synonyms: 4,5-dichloro-2-methyl-3(2h)-pyridazinon;AKOS B029262;4,5-DICHLORO-2-METHYLPYRIDAZIN-3[2H]-ONE;4,5-DICHLORO-2-METHYLPYRIDAZIN-3-ONE;4,5-DICHLORO-2-METHYLPYRIDAZINE-3(2H)-ONE;4,5-DICHLORO-2-METHYL-2,3-DIHYDROPYRIDAZIN-3-ONE;4,5-DICHLORO-2-METHYL-2H-PYRIDAZIN-3-ONE;4,5-DICHLORO-2-METHYL-3(2H)-PYRIDAZINONE
• CAS NO: 933-76-6
• Molecular Formula: C₅H₄Cl₂N₂O
• Molecular Weight: 179
• Product Categories: Halides;Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridazines
• Mol File: 933-76-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 87-91 °C(lit.)
• Boiling Point: 197.2 °C at 760 mmHg
• Flash Point: 73.1 °C
• Appearance: Off-white to yellow low crystalline powder
• Density: 1.55 g/cm³
• Vapor Pressure: 0.382mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Ethanol
• PKA: -3.57±0.20(Predicted)
• CAS DataBase Reference: 4,5-DICHLORO-2-METHYLPYRIDAZIN-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DICHLORO-2-METHYLPYRIDAZIN-3-ONE(933-76-6)
• EPA Substance Registry System: 4,5-DICHLORO-2-METHYLPYRIDAZIN-3-ONE(933-76-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: UR6188000
• Hazardous Substances Data: 933-76-6(Hazardous Substances Data)

Usage

Chemical Properties

Off-white to yellow low crystalline powder

Uses

4,5-Dichloro-2-methyl-3(2H)-pyridazinone can be used in the synthesis of 4-amino-3(2H)-pyridazinones and 5-amino-3(2H)-pyridazinones via reaction with N-benzylaminoethanol.

InChI:InChI=1/C5H4Cl2N2O/c1-9-5(10)4(7)3(6)2-8-9/h2H,1H3

Upstream product

• 766-40-5 Mucochloric acid 
• 302-15-8 methylhydrazine sulfuric acid 
• 60-34-4 methylhydrazine 
• 87-56-9 mucochloric acid 
• 932-22-9 4,5-dichloro-2H-pyridazin-3-one 
• 74-88-4 methyl iodide 
• 51355-97-6 4,5-dichloro-2-(hydroxymethyl)pyridazin-3(2H)-one 
• 867130-68-5 4,5-dichloro-1-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid 
• 872826-22-7 4,5-dichloro-2,6-dimethyl-pyridazin-3-one 
• 867130-30-1 5-chloro-2,6-dimethyl-2H-pyridazin-3-one 
• 50500-59-9 2,6-dimethyl-2H-pyridazin-3-one 

Downstream Products

• 153276-43-8 2-methyl-4-chloro-5-<4-(2-phenoxyethyl)-1-piperazinyl>-3(2H)-pyridazinone 
• 153276-41-6 2-methyl-4-chloro-5-<4-(2-methoxyphenoxyethyl)-1-piperazinyl>-3(2H)-pyridazinone 
• 14628-57-0 4-chloro-5-methoxy-2-methyl-2H-pyridazin-3-one 
• 143702-97-0 2-Cyclohexyl-4-cyclohexylamino-7-methyl-1-thioxo-1,2-dihydro-7H-5-thia-2,7,8,9b-tetraaza-cyclopenta[a]naphthalene-3,6-dione 
• 143702-96-9 7-Methyl-2-phenyl-4-phenylamino-1-thioxo-1,2-dihydro-7H-5-thia-2,7,8,9b-tetraaza-cyclopenta[a]naphthalene-3,6-dione 
• 268210-60-2 5-[N-benzyl-N-(3-hydroxypropyl)amino]-4-chloro-2-methyl-3(2H)-pyridazinone 
• 663953-56-8 4-chloro-2-methyl-5-phenylpyridazin-3(2H)-one 
• 38387-52-9 5-chloro-2-methyl-4-phenoxypyridazin-3(2H)-one 
• 214556-07-7 4-chloro-2-methyl-5-phenoxypyridazin-3(2H)-one 
• 66597-60-2 5-(N-benzyl-N-2-hydroxyethylamino)-4-chloro-2-methyl-3(2H)-pyridazinone 

Relevant articles and documents

Contrast agent and for the use of a synthetic composition, method and system (by machine translation)

The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

Functionalization of 4,5-Dichloropyridazin-3(2H)-one

The functionalization of 4,5-dichloropyridazin-3(2H)-one and 4,5-dichloro-2-methyl-6-nitropyridazin-3(2H)-one was reported. A mixture of 4,5-dichloropyridazin-3(2H)-one, potassium nitrate and conc-sulfuric acid was stirred for 5 hours at 110-120°C. After cooling to room temperature, the solution was slowly poured into ice-water. The resulting yellow crystals was filtered, washed with water and dried in air to give the product. A mixture of 4,5-dichloro-6- nitropyridazin-3(2H)-one and POCl3 was refluxed for 24 hours. After cooling to room temperature, the solution was evaporated under reduced pressure. The resulting residue was slowly poured into ice-water (300 mL). Chlorination of compound 4,5-dichloro-6- nitropyridazin-3(2H)-one with phosphorus oxychloride also gave 3,4,5-trichloro-6-nitropyridazine in 72% yield. Three proton signals were also detected at d 9.0 (1H), 8.64 (1H) and 6.20 (2H) ppm in the spectrum of 1H NMR.

HERBICIDAL PYRIDAZINONE DERIVATIVES

The present invention provides a compound of Formula (I) or an agronomically acceptable salt thereof, wherein:R2 is selected from the group consisting of (A1), (A2) and (A3) wherein X1 is N or CR7 X2 is N or CR8 X3 is N or CR9 X4 is N or CR6 R1, R3, R4, R5 R6, R7, R8 and R9 are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), and to their use for controlling weeds, in particular in crops of useful plants.