Technology Process of Methyl 2-cyano-5-methylhex-2-enoate
There total 1 articles about Methyl 2-cyano-5-methylhex-2-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
piperidine; acetic acid;
at 0 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 69 percent / KF/Al2O3 / acetonitrile / 2 h / Heating
2: 86 percent / NaBH4 / tetrahydrofuran; H2O / 20 °C
3: 48 percent / methanesulfonyl chloride; pyridine / CH2Cl2 / 2 h / 20 °C
4: 99 percent / sodium azide / dimethylformamide / 1 h / 100 °C
5: 96 percent / H2 / Pd/C / methanol / 8 h / 2482.31 Torr
With
pyridine; aluminum oxide; potassium fluoride; sodium tetrahydroborate; sodium azide; hydrogen; methanesulfonyl chloride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0491086
