3-[(2S,8R,9R)-11-[(2S)-1-[(tert-butyldimethylsilyl)oxy]propan-2-yl]-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

Base Information

Chemical Name:3-[(2S,8R,9R)-11-[(2S)-1-[(tert-butyldimethylsilyl)oxy]propan-2-yl]-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea
CAS No.:1403479-55-9
Molecular Formula:C₄₁H₅₉FN₄O₇SSi
Molecular Weight:799.092
Hs Code.:

3-[(2S,8R,9R)-11-[(2S)-1-[(tert-butyldimethylsilyl)oxy]propan-2-yl]-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

Synonyms:3-[(2S,8R,9R)-11-[(2S)-1-[(tert-butyldimethylsilyl)oxy]propan-2-yl]-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

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Chemical Property of 3-[(2S,8R,9R)-11-[(2S)-1-[(tert-butyldimethylsilyl)oxy]propan-2-yl]-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

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Technology Process of 3-[(2S,8R,9R)-11-[(2S)-1-[(tert-butyldimethylsilyl)oxy]propan-2-yl]-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

There total 10 articles about 3-[(2S,8R,9R)-11-[(2S)-1-[(tert-butyldimethylsilyl)oxy]propan-2-yl]-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1255397-71-7
3-[(2S,8R,9R)-11-((S)-1-hydroxypropan-2-yl)-2,9-dimethyl-8-[(N-methyl(4-fluorobenzene)sulfonamido)methyl]-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxaazacyclotetradecin-14-yl]-1-phenylurea

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1403479-55-9
3-[(2S,8R,9R)-11-[(2S)-1-[(tert-butyldimethylsilyl)oxy]propan-2-yl]-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 15h; Inert atmosphere;

Reference yield:

: 1255214-08-4
allyl (((2S,8R,9R)-14-((((9H-fIuoren-9-yl)methoxy)carbonyl)amino)-11-((S)-1-hydroxypropan-2-yl)-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)(methyl)carbamate

: 1403479-55-9
3-[(2S,8R,9R)-11-[(2S)-1-[(tert-butyldimethylsilyl)oxy]propan-2-yl]-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: piperidine / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

4: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 1 h / 20 °C / Inert atmosphere

5: 2,6-dimethylpyridine / dichloromethane / 15 h / 20 °C / Inert atmosphere

6: potassium carbonate / methanol / 15 h / 20 °C / Inert atmosphere

7: 1H-imidazole / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

With piperidine; pyridine; 1H-imidazole; 2,6-dimethylpyridine; 1,3-dimethylbarbituric acid; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: C₃₃H₄₅N₃O₇

: 1403479-55-9
3-[(2S,8R,9R)-11-[(2S)-1-[(tert-butyldimethylsilyl)oxy]propan-2-yl]-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: 2,6-dimethylpyridine / dichloromethane / 15 h / 20 °C / Inert atmosphere

4: potassium carbonate / methanol / 15 h / 20 °C / Inert atmosphere

5: 1H-imidazole / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

With 1H-imidazole; 2,6-dimethylpyridine; 1,3-dimethylbarbituric acid; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide;