5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid phenylamide

Base Information

Chemical Name:5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid phenylamide
CAS No.:213771-63-2
Molecular Formula:C₂₀H₁₄Br₂ClIN₂O
Molecular Weight:620.509
Hs Code.:

Synonyms:5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid phenylamide

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Chemical Property of 5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid phenylamide

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Technology Process of 5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid phenylamide

There total 6 articles about 5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 213771-04-1
1-bromo-3-(bromomethyl)-5-chloro-2-iodobenzene

: 213771-38-1
3-methyl-5-bromopyridine-2-N-phenylamide

: 213771-63-2
5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid phenylamide

Guidance literature:: 3-methyl-5-bromopyridine-2-N-phenylamide; With n-butyllithium; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; hexanes; tert-butyl methyl ether; at -50 ℃;

1-bromo-3-(bromomethyl)-5-chloro-2-iodobenzene; In tetrahydrofuran; hexanes; tert-butyl methyl ether; at -40 ℃;

Reference yield:

: C₇H₄BrClN₂O₂

: 213771-63-2
5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / KI / H₂O

2: 98 percent / (MeO)3B; BH₃*Me₂S / tetrahydrofuran / 18 h / 20 °C

3: 96 percent / Br₂; PPh₃ / acetonitrile / 1 h / 20 °C

4: LDA; t-BuOMe / tetrahydrofuran; various solvent(s) / -40 - 0 °C

With Trimethyl borate; tert-butyl methyl ether; dimethylsulfide borane complex; bromine; triphenylphosphine; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/ol016809d

Reference yield:

: 41198-02-1
2-amino-3-bromo-5-chlorobenzoic acid

: 213771-63-2
5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 5 steps

1: NaNO₂; conc. H₂SO₄ / 3 h / 0 °C

2: 87 percent / KI / H₂O

3: 98 percent / (MeO)3B; BH₃*Me₂S / tetrahydrofuran / 18 h / 20 °C

4: 96 percent / Br₂; PPh₃ / acetonitrile / 1 h / 20 °C

5: LDA; t-BuOMe / tetrahydrofuran; various solvent(s) / -40 - 0 °C

With Trimethyl borate; tert-butyl methyl ether; dimethylsulfide borane complex; sulfuric acid; bromine; triphenylphosphine; potassium iodide; lithium diisopropyl amide; sodium nitrite; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/ol016809d