5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid methyl-phenyl-amide

Base Information

Chemical Name:5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid methyl-phenyl-amide
CAS No.:213771-69-8
Molecular Formula:C₂₁H₁₆Br₂ClIN₂O
Molecular Weight:634.536
Hs Code.:

Synonyms:5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid methyl-phenyl-amide

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Chemical Property of 5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid methyl-phenyl-amide

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Technology Process of 5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid methyl-phenyl-amide

There total 8 articles about 5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid methyl-phenyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 213771-63-2
5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid phenylamide

: 74-88-4
methyl iodide

: 213771-69-8
5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid methyl-phenyl-amide

Guidance literature:: 5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid phenylamide; With sodium hydride; In N,N-dimethyl-formamide; at -10 ℃; for 1h;

methyl iodide; In N,N-dimethyl-formamide; at -10 ℃; for 1h; Further stages.;
DOI:10.1021/ol016809d

Reference yield: 44.0%

: 213771-04-1
1-bromo-3-(bromomethyl)-5-chloro-2-iodobenzene

: 213771-38-1
3-methyl-5-bromopyridine-2-N-phenylamide

: 213771-69-8
5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid methyl-phenyl-amide

Guidance literature:: 3-methyl-5-bromopyridine-2-N-phenylamide; With n-butyllithium; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; at -78 - -60 ℃; for 0.0833333h;

With zinc dibromide; In tetrahydrofuran;

1-bromo-3-(bromomethyl)-5-chloro-2-iodobenzene; In tetrahydrofuran; for 2h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: C₇H₄BrClN₂O₂

: 213771-69-8
5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid methyl-phenyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 87 percent / KI / H₂O

2.1: 98 percent / (MeO)3B; BH₃*Me₂S / tetrahydrofuran / 18 h / 20 °C

3.1: 96 percent / Br₂; PPh₃ / acetonitrile / 1 h / 20 °C

4.1: LDA; t-BuOMe / tetrahydrofuran; various solvent(s) / -40 - 0 °C

5.1: NaH / dimethylformamide / 1 h / -10 °C

5.2: 85 percent / dimethylformamide / 1 h / -10 °C

With Trimethyl borate; tert-butyl methyl ether; dimethylsulfide borane complex; bromine; sodium hydride; triphenylphosphine; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol016809d