dimethyl 2-(3-(1-methyl-1H-imidazol-2-yl)-3-oxo-1-phenylpropyl)malonate

Base Information

Chemical Name:dimethyl 2-(3-(1-methyl-1H-imidazol-2-yl)-3-oxo-1-phenylpropyl)malonate
CAS No.:1185267-52-0
Molecular Formula:C₁₈H₂₀N₂O₅
Molecular Weight:344.367
Hs Code.:

Synonyms:dimethyl 2-(3-(1-methyl-1H-imidazol-2-yl)-3-oxo-1-phenylpropyl)malonate

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Chemical Property of dimethyl 2-(3-(1-methyl-1H-imidazol-2-yl)-3-oxo-1-phenylpropyl)malonate

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Technology Process of dimethyl 2-(3-(1-methyl-1H-imidazol-2-yl)-3-oxo-1-phenylpropyl)malonate

There total 4 articles about dimethyl 2-(3-(1-methyl-1H-imidazol-2-yl)-3-oxo-1-phenylpropyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 99802-91-2
2-cinnamoyl-1-methyl-1H-imidazole

: 108-59-8
malonic acid dimethyl ester

: 1185267-52-0
dimethyl 2-(3-(1-methyl-1H-imidazol-2-yl)-3-oxo-1-phenylpropyl)malonate

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 20h; Reagent/catalyst;
DOI:10.1021/jacs.0c13251

Reference yield: 40.0%

: 860772-43-6
(E)-1-(1-methyl-1H-imidazole-2-yl)-3-phenylprop-2-en-1-one

: 108-59-8
malonic acid dimethyl ester

: 1185267-52-0
dimethyl 2-(3-(1-methyl-1H-imidazol-2-yl)-3-oxo-1-phenylpropyl)malonate

Guidance literature:: With 4,4'-dimethyl-2,2'-bipyridines; copper(II) nitrate trihydrate; In acetonitrile; at 20 ℃; for 72h; Inert atmosphere;
DOI:10.1002/anie.201306232

Reference yield:

: 85692-37-1
1-(1-methyl-1H-imidazol-2-yl)ethan-1-one

: 1185267-52-0
dimethyl 2-(3-(1-methyl-1H-imidazol-2-yl)-3-oxo-1-phenylpropyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 48 h / 20 °C / Inert atmosphere

2: 4,4'-dimethyl-2,2'-bipyridines; copper(II) nitrate trihydrate / acetonitrile / 72 h / 20 °C / Inert atmosphere

With 4,4'-dimethyl-2,2'-bipyridines; copper(II) nitrate trihydrate; potassium hydroxide; In ethanol; acetonitrile; 2: |Friedel-Crafts Alkylation;
DOI:10.1002/anie.201306232