(2R,3S)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-nitrophenyl)propanoic acid

Base Information

• Chemical Name: (2R,3S)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-nitrophenyl)propanoic acid
• CAS No.: 1172585-16-8
• Molecular Formula: C₁₄H₁₈N₂O₇
• Molecular Weight: 326.306
• Mol file: 1172585-16-8.mol

Synonyms:(2R,3S)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-nitrophenyl)propanoic acid

Chemical Property of (2R,3S)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-nitrophenyl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-nitrophenyl)propanoic acid

There total 1 articles about (2R,3S)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-nitrophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

(1S,2S)-(+)-2-tert-butoxycarbonylamino-1-(4-nitrophenyl)-1,3-propanediol (647376-90-7) → (2R,3S)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-nitrophenyl)propanoic acid (1172585-16-8)

Guidance literature:

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; sodium hydrogencarbonate; In acetone; at 0 ℃; for 0.25h;

DOI:10.1016/j.bmc.2009.04.038

Reference yield: 88.7%

(2R,3S)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-nitrophenyl)propanoic acid (1172585-16-8) + methyl (L)-leucinate hydrochloride (7517-19-3) → C21H31N3O8 (1172585-51-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2009.04.038

Reference yield: 86.0%

propylamine (107-10-8,42939-71-9) + (2R,3S)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-nitrophenyl)propanoic acid (1172585-16-8) → C17H25N3O6 (1172585-18-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2009.04.038

upstream raw materials:

(1S,2S)-(+)-2-tert-butoxycarbonylamino-1-(4-nitrophenyl)-1,3-propanediol

Downstream raw materials:

C₁₇H₂₅N₃O₆

C₂₂H₂₇N₃O₇

(2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propionic acid

C₂₂H₂₆ClN₃O₆