(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-bromomethyl-myo-inositol

Base Information

Chemical Name:(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-bromomethyl-myo-inositol
CAS No.:403651-40-1
Molecular Formula:C₄₃H₄₅BrO₆
Molecular Weight:737.731
Hs Code.:

Synonyms:(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-bromomethyl-myo-inositol

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Chemical Property of (-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-bromomethyl-myo-inositol

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Technology Process of (-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-bromomethyl-myo-inositol

There total 4 articles about (-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-bromomethyl-myo-inositol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 403651-37-6
(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-hydroxymethyl-myo-inositol

: 403651-40-1
(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-bromomethyl-myo-inositol

Guidance literature:: With pyridine; carbon tetrabromide; triphenylphosphine; at 0 - 70 ℃; for 2h;
DOI:10.1016/S0968-0896(01)00232-2

Reference yield:

: 141040-56-4
(+)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol

: 403651-40-1
(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-bromomethyl-myo-inositol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / Ac₂O / dimethylsulfoxide / 23 °C

2.1: potassium t-butoxide / toluene / 0.5 h / Heating

2.2: 80 percent / toluene / 2 h / 100 - 110 °C

3.1: 9-BBN / benzene; tetrahydrofuran / 20 °C

3.2: 71 percent / NaOH; H₂O₂ / benzene; tetrahydrofuran; methanol / 2 h / 55 °C

4.1: 79 percent / CBr₄; Ph₃P; pyridine / 2 h / 0 - 70 °C

With pyridine; 9-borabicyclo[3.3.1]nonane dimer; carbon tetrabromide; potassium tert-butylate; acetic anhydride; triphenylphosphine; In tetrahydrofuran; dimethyl sulfoxide; toluene; benzene; 2.2: Wittig reaction;
DOI:10.1016/S0968-0896(01)00232-2

Reference yield:

: 403651-35-4
(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-oxo-myo-inositol

: 403651-40-1
(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-bromomethyl-myo-inositol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium t-butoxide / toluene / 0.5 h / Heating

1.2: 80 percent / toluene / 2 h / 100 - 110 °C

2.1: 9-BBN / benzene; tetrahydrofuran / 20 °C

2.2: 71 percent / NaOH; H₂O₂ / benzene; tetrahydrofuran; methanol / 2 h / 55 °C

3.1: 79 percent / CBr₄; Ph₃P; pyridine / 2 h / 0 - 70 °C

With pyridine; 9-borabicyclo[3.3.1]nonane dimer; carbon tetrabromide; potassium tert-butylate; triphenylphosphine; In tetrahydrofuran; toluene; benzene; 1.2: Wittig reaction;
DOI:10.1016/S0968-0896(01)00232-2