(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-oxo-myo-inositol

Base Information

Chemical Name:(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-oxo-myo-inositol
CAS No.:403651-35-4
Molecular Formula:C₄₂H₄₂O₇
Molecular Weight:658.791
Hs Code.:

Synonyms:(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-oxo-myo-inositol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-oxo-myo-inositol

Chemical Property:

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Technology Process of (-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-oxo-myo-inositol

There total 1 articles about (-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-oxo-myo-inositol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 141040-56-4
(+)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol

: 403651-35-4
(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-oxo-myo-inositol

Guidance literature:: With acetic anhydride; In dimethyl sulfoxide; at 23 ℃;
DOI:10.1016/S0968-0896(01)00232-2

Reference yield: 80.0%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 403651-35-4
(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-oxo-myo-inositol

: 403651-36-5
(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-methylene-myo-inositol

Guidance literature:: Methyltriphenylphosphonium bromide; With potassium tert-butylate; In toluene; for 0.5h; Heating;

(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-oxo-myo-inositol; In toluene; at 100 - 110 ℃; for 2h;
DOI:10.1016/S0968-0896(01)00232-2

Reference yield:

: 403651-35-4
(-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-3-deoxy-3-oxo-myo-inositol

: L-α-phosphatidyl-D-3-deoxy-3-fluoromethyl-myo-inositol

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium t-butoxide / toluene / 0.5 h / Heating

1.2: 80 percent / toluene / 2 h / 100 - 110 °C

2.1: 9-BBN / benzene; tetrahydrofuran / 20 °C

2.2: 71 percent / NaOH; H₂O₂ / benzene; tetrahydrofuran; methanol / 2 h / 55 °C

3.1: 75 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 2 h / 0 - 25 °C

4.1: 90 percent / trifluoroacetic acid / CH₂Cl₂; methanol / 1 h / 0 °C

5.1: 1H-tetrazole / CH₂Cl₂ / 0.5 h / 23 °C

5.2: CH₂Cl₂ / 12 h / 23 °C

5.3: 85 percent / m-CPBA / CH₂Cl₂ / 1.5 h / -40 - 20 °C

6.1: 97 percent / H₂ / Pd / ethanol; H₂O / 16 h / 2844.31 Torr

With 1H-tetrazole; 9-borabicyclo[3.3.1]nonane dimer; diethylamino-sulfur trifluoride; potassium tert-butylate; hydrogen; trifluoroacetic acid; palladium; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; benzene; 1.2: Wittig reaction;
DOI:10.1016/S0968-0896(01)00232-2