7-(2-aminoethyl)-3-(1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yI)furo[3,2-c]pyridin-4-amine

Base Information

Chemical Name:7-(2-aminoethyl)-3-(1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yI)furo[3,2-c]pyridin-4-amine
CAS No.:1337532-02-1
Molecular Formula:C₂₅H₂₂F₂N₄O₂
Molecular Weight:448.472
Hs Code.:

Synonyms:7-(2-aminoethyl)-3-(1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yI)furo[3,2-c]pyridin-4-amine

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Chemical Property of 7-(2-aminoethyl)-3-(1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yI)furo[3,2-c]pyridin-4-amine

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Technology Process of 7-(2-aminoethyl)-3-(1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yI)furo[3,2-c]pyridin-4-amine

There total 5 articles about 7-(2-aminoethyl)-3-(1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yI)furo[3,2-c]pyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.41%

: 1337531-97-1
phenylmethyl [2-(4-amino-3-(1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yI)furo[3,2-c]pyridin-7-yI)ethyl]carbamate

: 1337532-02-1
7-(2-aminoethyl)-3-(1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yI)furo[3,2-c]pyridin-4-amine

Guidance literature:: phenylmethyl [2-(4-amino-3-(1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yI)furo[3,2-c]pyridin-7-yI)ethyl]carbamate; With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; for 22h;

With hydrogenchloride; trifluoroacetic acid; In methanol; at 20 - 50 ℃; for 21h;

Reference yield:

: 1337532-96-3
3-(1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7-iodofuro[3,2-c]pyridin-4-amine

: 1337532-02-1
7-(2-aminoethyl)-3-(1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yI)furo[3,2-c]pyridin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dmap / dichloromethane / 17 h / 20 °C / Inert atmosphere

2.1: caesium carbonate / palladium diacetate; ruphos / toluene; water / 16 h / 95 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 22 h

4.2: 21 h / 20 - 50 °C

With hydrogenchloride; hydrogen; caesium carbonate; triethylamine; dmap; palladium 10% on activated carbon; palladium diacetate; ruphos; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1337531-46-0
3-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}furo[3,2-c]pyridin-4-amine

: 1337532-02-1
7-(2-aminoethyl)-3-(1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yI)furo[3,2-c]pyridin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 18 h / -40 - 20 °C

2.1: triethylamine / dmap / dichloromethane / 17 h / 20 °C / Inert atmosphere

3.1: caesium carbonate / palladium diacetate; ruphos / toluene; water / 16 h / 95 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere

5.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 22 h

5.2: 21 h / 20 - 50 °C

With hydrogenchloride; N-iodo-succinimide; hydrogen; caesium carbonate; triethylamine; dmap; palladium 10% on activated carbon; palladium diacetate; ruphos; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;