1,3-bis-{(N₁'-[3'',4''-bis(benzyloxy)benzoyl]-N₄'-acetyl)spermidinyl}-2-isopropyl citrate

Base Information

• Chemical Name: 1,3-bis-{(N₁'-[3'',4''-bis(benzyloxy)benzoyl]-N₄'-acetyl)spermidinyl}-2-isopropyl citrate
• CAS No.: 1608483-51-7
• Molecular Formula: C₆₉H₈₄N₆O₁₃
• Molecular Weight: 1205.46

Synonyms:1,3-bis-{(N₁'-[3'',4''-bis(benzyloxy)benzoyl]-N₄'-acetyl)spermidinyl}-2-isopropyl citrate

Chemical Property of 1,3-bis-{(N₁'-[3'',4''-bis(benzyloxy)benzoyl]-N₄'-acetyl)spermidinyl}-2-isopropyl citrate

Chemical Property:

Purity/Quality:

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Technology Process of 1,3-bis-{(N₁'-[3'',4''-bis(benzyloxy)benzoyl]-N₄'-acetyl)spermidinyl}-2-isopropyl citrate

There total 2 articles about 1,3-bis-{(N₁'-[3'',4''-bis(benzyloxy)benzoyl]-N₄'-acetyl)spermidinyl}-2-isopropyl citrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N1-[3,4-bis(benzyloxy)benzoyl]-N4-acetyl spermidine TFA salt (1608483-45-9) + 2-isopropyl citrate (83966-25-0) → 1,3-bis-{(N1'-[3'',4''-bis(benzyloxy)benzoyl]-N4'-acetyl)spermidinyl}-2-isopropyl citrate (1608483-51-7)

Guidance literature:

N₁-[3,4-bis(benzyloxy)benzoyl]-N₄-acetyl spermidine TFA salt; With triethylamine; In N,N-dimethyl-formamide; for 0.25h; Cooling with ice; Inert atmosphere; Darkness;

2-isopropyl citrate; In N,N-dimethyl-formamide; at 20 ℃; Molecular sieve; Cooling with ice; Ionic liquid; Darkness;

DOI:10.1002/ejoc.201301340

Reference yield:

2-Hydroxy-1,2,3-propanetricarboxylic Acid 2-Isopropyl Ester (83966-24-9) → 1,3-bis-{(N1'-[3'',4''-bis(benzyloxy)benzoyl]-N4'-acetyl)spermidinyl}-2-isopropyl citrate (1608483-51-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide / acetonitrile / 20 h / 20 °C / Inert atmosphere

2.1: triethylamine / N,N-dimethyl-formamide / 0.25 h / Cooling with ice; Inert atmosphere; Darkness

2.2: 20 °C / Molecular sieve; Cooling with ice; Ionic liquid; Darkness

With triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/ejoc.201301340

Reference yield:

1,3-bis-{(N1'-[3'',4''-bis(benzyloxy)benzoyl]-N4'-acetyl)spermidinyl}-2-isopropyl citrate (1608483-51-7) → C66H78N6O13 (1608483-56-2)

Guidance literature:

1,3-bis-{(N₁'-[3'',4''-bis(benzyloxy)benzoyl]-N₄'-acetyl)spermidinyl}-2-isopropyl citrate; With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 0.666667h; Inert atmosphere; Darkness;

In tetrahydrofuran; water; for 0.166667h; Inert atmosphere;

DOI:10.1002/ejoc.201301340

upstream raw materials:

N₁-[3,4-bis(benzyloxy)benzoyl]-N₄-acetyl spermidine TFA salt

2-isopropyl citrate

2-Hydroxy-1,2,3-propanetricarboxylic Acid 2-Isopropyl Ester

Downstream raw materials:

C₆₆H₇₈N₆O₁₃

1,3-bis{(N₁'-[3'',4''-bis(hydroxy)benzoyl]-N₄'-acetyl)spermidinyl} citrate

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