Technology Process of trans-8-chloro-5-methanesulfonyl-1-(4-phenyl-cyclohexyl)-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene
There total 12 articles about trans-8-chloro-5-methanesulfonyl-1-(4-phenyl-cyclohexyl)-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 19h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: dmap / dichloromethane / 18 h / 0 - 20 °C
2: hydrogen; zinc dibromide / palladium 10% on activated carbon / ethyl acetate / 48 h / 760.05 Torr
3: potassium tert-butylate / tetrahydrofuran / 3 h / 5 - 20 °C
4: Lawessons reagent / tetrahydrofuran / 3 h / Reflux
5: butan-1-ol / Reflux
6: hydrogenchloride / 50 °C
7: triethylamine / dichloromethane / 19 h / 20 °C
With
Lawessons reagent; hydrogenchloride; dmap; potassium tert-butylate; hydrogen; triethylamine; zinc dibromide;
palladium 10% on activated carbon;
In
tetrahydrofuran; dichloromethane; ethyl acetate; butan-1-ol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydrogen; zinc dibromide / palladium 10% on activated carbon / ethyl acetate / 48 h / 760.05 Torr
2: potassium tert-butylate / tetrahydrofuran / 3 h / 5 - 20 °C
3: Lawessons reagent / tetrahydrofuran / 3 h / Reflux
4: butan-1-ol / Reflux
5: hydrogenchloride / 50 °C
6: triethylamine / dichloromethane / 19 h / 20 °C
With
Lawessons reagent; hydrogenchloride; potassium tert-butylate; hydrogen; triethylamine; zinc dibromide;
palladium 10% on activated carbon;
In
tetrahydrofuran; dichloromethane; ethyl acetate; butan-1-ol;