BOC-TYR(PO3ME2)-OH

Base Information

• Chemical Name: BOC-TYR(PO3ME2)-OH
• CAS No.: 92264-99-8
• Molecular Formula: C16H24 N O8 P
• Molecular Weight: 389.342
• Mol file: 92264-99-8.mol

Synonyms:BOC-O-DIMETHYLPHOSPHO-L-TYROSINE;BOC-TYR(PO3ME2)-OH;BOC-TYROSINE(PO3ME2)-OH;N-ALPHA-T-BUTOXYCARBONYL-O-DIMETHYLPHOSPHONO-L-TYROSINE;N-ALPHA-T-BUTOXYCARBONYL-O-DIMETHYLPHOSPHENO-L-TYROSINE;n伪-boc-o-(dimethylphospho)-l-tyrosine

Chemical Property of BOC-TYR(PO3ME2)-OH

Chemical Property:

• Vapor Pressure: 4.92E-11mmHg at 25°C
• Refractive Index: 1.514
• Boiling Point: 505.4°C at 760 mmHg
• Flash Point: 259.4°C
• PSA: 130.20000
• Density: 1.272g/cm³
• LogP: 3.37760
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Boc-Tyr(PO3Me2)-OH ≥96.0% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-TYR(PO3ME2)-OH

There total 8 articles about BOC-TYR(PO3ME2)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(tert-Butoxycarbonyl)-O-(dimethylphosphono)-L-tyrosyl p-nitrobenzyl ester (92264-96-5) → Nα-(tert-butoxycarbonyl)-O-(O',O''-dimethylphosphoro)-L-tyrosine (92264-99-8)

Guidance literature:

With hydrogen; palladium; In methanol; acetic acid;

DOI:10.1016/S0040-4039(01)81243-0

Reference yield: 75.0%

Nα-(tert-butoxycarbonyl)-O-(dimethylphosphono)tyrosine anthraquinon-2-ylmethyl ester (127103-00-8) → Nα-(tert-butoxycarbonyl)-O-(O',O''-dimethylphosphoro)-L-tyrosine (92264-99-8)

Guidance literature:

With sodium dithionite; sodium carbonate; In water; acetonitrile; at 50 ℃; for 1h;

DOI:10.1021/jo00300a041

Reference yield:

N-(tert-butoxycarbonyl)-L-tyrosyl p-nitrobenzyl ester (92264-95-4) → Nα-(tert-butoxycarbonyl)-O-(O',O''-dimethylphosphoro)-L-tyrosine (92264-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 60.9 percent / triethylamine / CCl₄; ethyl acetate / 24 h / 23 °C

2: 93.4 percent / H₂ / 10percent Pd/C / methanol; acetic acid / 3 h / 23 °C / 2068.6 Torr

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; tetrachloromethane; acetic acid; ethyl acetate;

DOI:10.1021/jo00087a025

upstream raw materials:

N^α-(tert-butoxycarbonyl)-O-(dimethylphosphono)tyrosine anthraquinon-2-ylmethyl ester

N-(tert-Butoxycarbonyl)-O-(dimethylphosphono)-L-tyrosyl p-nitrobenzyl ester

N-(tert-butoxycarbonyl)-L-tyrosyl p-nitrobenzyl ester

Boc-Tyr-OH

Downstream raw materials:

TFA*H-Tyr(PO₃Me₂)-Val-OMaq

cyclo